LEADER 00738nam0-22002531i-450- 001 990003484330403321 005 20040115175836.0 035 $a000348433 035 $aFED01000348433 035 $a(Aleph)000348433FED01 035 $a000348433 100 $a20030910d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aDall'epica alla cronaca nella Russia soviettista$fEttore Lo Gatto 210 $aRoma$c[s.n.]$d[19..] 700 1$aLo Gatto,$bEttore$f<1890-1983>$05182 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003484330403321 952 $aSE 021.01.17-$b13540$fDECSE 959 $aDECSE 996 $aDall'epica alla cronaca nella Russia soviettista$9496268 997 $aUNINA LEADER 02236nam 2200421z- 450 001 9910346749103321 005 20210211 035 $a(CKB)4920000000094223 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53224 035 $a(oapen)doab53224 035 $a(EXLCZ)994920000000094223 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMetabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions 210 $cFrontiers Media SA$d2018 215 $a1 online resource (70 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-484-3 330 $aProliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor's origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer. 606 $aMedicine$2bicssc 610 $acancer metabolism 610 $alipogenesis 610 $ametabolic adaptation 610 $amitochondria 610 $aobesity 610 $aproliferation 610 $aWarburg effect 615 7$aMedicine 700 $aLluis Fajas$4auth$01318742 702 $aAlbert Giralt$4auth 906 $aBOOK 912 $a9910346749103321 996 $aMetabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions$93033508 997 $aUNINA