LEADER 02163nam  2200385z- 450 
001 9910346749103321
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035   $a(CKB)4920000000094223
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53224
035   $a(EXLCZ)994920000000094223
100   $a20202102d2018      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMetabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
210   $cFrontiers Media SA$d2018
215   $a1 electronic resource (70 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-484-3 
330   $aProliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor?s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.
610   $acancer metabolism
610   $aproliferation
610   $amitochondria
610   $alipogenesis
610   $ametabolic adaptation
610   $aobesity
610   $aWarburg effect
700   $aLluis Fajas$4auth$01318742
702   $aAlbert Giralt$4auth
906   $aBOOK
912   $a9910346749103321
996   $aMetabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions$93033508
997   $aUNINA