LEADER 01430nam0 22003131i 450 001 RML0299193 005 20231121125742.0 100 $a20121121d1995 ||||0itac50 ba 101 | $aita 102 $ait 181 1$6z01$ai $bxxxe 182 1$6z01$an 200 1 $aAcculturazione e mutamenti$eprospettive nell'archeologioa medievale del Mediterraneo$fa cura di Enrico9Boldrini, Riccardo Francovich 210 $aFirenze $cAll'insegna del giglio $d1995 215 $a406 p.$cfig.$d23 cm 225 | $aQuaderni del dipartimento di Archeologia e Storia delle Arti. - Firenze $eAll'insegna del giglio 300 $aIn testa al front.: Consiglio Nazionale delle Ricerche; Università degli Studi di Siena 410 0$1001RML0332018$12001 $aQuaderni del dipartimento di Archeologia e Storia delle Arti. - Firenze $eAll'insegna del giglio 606 $aScavo archeologico -Teoria$2FIR$3RMLC378975$9I 702 1$aFrancovich$b, Riccardo$3RMLV159618 702 1$aBoldrini$b, Enrico$3RMLV193161 801 3$aIT$bIT-01$c20121121 850 $aIT-FR0017 899 $aBiblioteca umanistica Giorgio Aprea$bFR0017 912 $aRML0299193 950 0$aBiblioteca umanistica Giorgio Aprea$d 52CIS 11/287$e 52VM 0000690925 VM barcode:67354-10. - Inventario:10856 FLSVM$fA $h20070601$i20121204 977 $a 52 996 $aAcculturazione e mutamenti$9877458 997 $aUNICAS LEADER 03371nam 2200445z- 450 001 9910346748803321 005 20210211 035 $a(CKB)4920000000094226 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43101 035 $a(oapen)doab43101 035 $a(EXLCZ)994920000000094226 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Chemistry of Imaging Probes 210 $cFrontiers Media SA$d2018 215 $a1 online resource (129 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-598-X 330 $aOver the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential. 606 $aChemistry$2bicssc 610 $aChelating Ligands 610 $aContrast Agents 610 $aCoordination Chemistry 610 $aMagnetic Resonance Imaging 610 $aMolecular Imaging Probes 610 $aPositron Emission Tomography 610 $aSingle Photon Emission Computed Tomography 610 $aThermodynamic and Kinetic stability 610 $aUltrasound 615 7$aChemistry 700 $aLorenzo Tei$4auth$01296175 702 $aZsolt Baranyai$4auth 906 $aBOOK 912 $a9910346748803321 996 $aThe Chemistry of Imaging Probes$93023849 997 $aUNINA