LEADER 02494nam  2200397z- 450 
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005 20231214133442.0
035   $a(CKB)4920000000094274
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41245
035   $a(EXLCZ)994920000000094274
100   $a20202102d2018      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAre Rodent Models Fit for Investigation of Human Obesity and Related Diseases?
210   $cFrontiers Media SA$d2018
215   $a1 electronic resource (161 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-425-8 
330   $aNot only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
610   $aObesity
610   $adisease
610   $anon-alcoholic fatty liver disease
610   $arodent models
610   $atype 2 diabetes mellitus
700   $aRobert K. Semple$4auth$01331081
702   $aSam Virtue$4auth
702   $aGilles Fromentin$4auth
702   $aPatrick C. Even$4auth
702   $aNicholas M. Morton$4auth
906   $aBOOK
912   $a9910346744003321
996   $aAre Rodent Models Fit for Investigation of Human Obesity and Related Diseases$93040109
997   $aUNINA