LEADER 03703nam 2200457z- 450 001 9910346743503321 005 20210211 035 $a(CKB)4920000000094279 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42869 035 $a(oapen)doab42869 035 $a(EXLCZ)994920000000094279 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCellular Mechanisms of Ototoxicity 210 $cFrontiers Media SA$d2018 215 $a1 online resource (292 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-483-5 330 $aThe auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE's mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder. 606 $aNeurosciences$2bicssc 610 $aaminoglycosides 610 $ablood-labyrinth barrier 610 $acisplatin 610 $aneurotoxicity 610 $aotoprotection 610 $aototoxic synergy 610 $asensory disorders 615 7$aNeurosciences 700 $aCarlos Esquivel$4auth$01317902 702 $aKelly Watts$4auth 702 $aPeter S. Steyger$4auth 702 $aJian Zuo$4auth 702 $aLisa Cunningham$4auth 906 $aBOOK 912 $a9910346743503321 996 $aCellular Mechanisms of Ototoxicity$93033072 997 $aUNINA