LEADER 03459nam  2200469z- 450 
001 9910346741903321
005 20210212
035   $a(CKB)4920000000094295
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57915
035   $a(oapen)doab57915
035   $a(EXLCZ)994920000000094295
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aRedox and Metabolic Circuits in Cancer
210   $cFrontiers Media SA$d2018
215   $a1 online resource (183 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-635-8 
330   $aLiving cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their "individualistic" behavior under a teleonomic viewpoint.
606   $aMedicine$2bicssc
610   $aAutophagy
610   $aBioenergetics
610   $aCancer Metabolism
610   $ahypoxia
610   $aMitochondria
610   $aredox
610   $aROS
610   $aS-nitrosylation
610   $aWarburg effect
615  7$aMedicine
700   $aSalvatore Rizza$4auth$01320441
702   $aGiuseppe Filomeni$4auth
702   $aAndrea Rasola$4auth
702   $aDanyelle M. Townsend$4auth
906   $aBOOK
912   $a9910346741903321
996   $aRedox and Metabolic Circuits in Cancer$93034312
997   $aUNINA