LEADER 02405nam 2200481z- 450 001 9910346739703321 005 20210211 035 $a(CKB)4920000000094317 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55410 035 $a(oapen)doab55410 035 $a(EXLCZ)994920000000094317 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aOrganogenesis From Development to Disease 210 $cFrontiers Media SA$d2017 215 $a1 online resource (110 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-318-9 330 $aDuring embryonic development there are many processes that must take place to produce a viable and healthy fetus. Alterations in the cellular and/or molecular interactions within any particular organ can cause catastrophic defects leading to defective organogenesis and death of the embryo. Even slight malformations of the organs can cause developmental reprogramming and increase the likelihood of adult onset diseases. The use of experimental animals with genetic mutations that mimic many human conditions has lead to significant scientific advancement of these complex and multifaceted diseases. Furthermore, the utilization of organ culture systems has made for profound insights into the formation of organs. Over recent years, the technology related to molecular profiling and imaging of developing organs has dramatically improved, leading to the identification of subtle genetic and phenotypic alterations. This research topic will focus on the area of organ formation and modeling of human developmental diseases. 606 $aBiology, life sciences$2bicssc 610 $aAnimal 610 $aBladder innervation 610 $abone mineralization 610 $aBowel disease 610 $aDevelopmental Biology 610 $aDiabetes Mellitus 610 $aDisease Models 610 $aInflammation 610 $akidney development 610 $aOrganogenesis 610 $aType 1 615 7$aBiology, life sciences 700 $aMisty Good$4auth$01292352 702 $aSeppo Vainio$4auth 702 $aSunder Sims-Lucas$4auth 906 $aBOOK 912 $a9910346739703321 996 $aOrganogenesis From Development to Disease$93022204 997 $aUNINA