LEADER 03037nam  2200445z- 450 
001 9910346739203321
005 20210211
035   $a(CKB)4920000000094322
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53628
035   $a(oapen)doab53628
035   $a(EXLCZ)994920000000094322
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer
210   $cFrontiers Media SA$d2018
215   $a1 online resource (123 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-389-8 
330   $aThe human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a "copy and paste" mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS).To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
606   $aChemistry$2bicssc
610   $acellular differentiation
610   $aDNA repair
610   $agenome stability
610   $aMobile DNA
610   $amodel organisms
610   $aretrotransposon
610   $areverse transcriptase
610   $aRNA-dependent DNA polymerase
610   $atransposon
615  7$aChemistry
700   $aJose Luis Garcia Perez$4auth$01325055
702   $aTammy A. Morrish$4auth
906   $aBOOK
912   $a9910346739203321
996   $aMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer$93036524
997   $aUNINA