LEADER 02242nam  2200457z- 450 
001 9910346738003321
005 20210211
035   $a(CKB)4920000000094334
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50580
035   $a(oapen)doab50580
035   $a(EXLCZ)994920000000094334
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aIntrinsic Clocks
210   $cFrontiers Media SA$d2018
215   $a1 online resource (117 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-451-7 
330   $a"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called "clock genes."
606   $aMedicine and Nursing$2bicssc
610   $acircadian
610   $acryptochrome
610   $adiurnal
610   $ahippocampus
610   $amood
610   $anocturnal
610   $aoscillation
610   $aseasonal
610   $asmall-molecule
610   $atanycytes
615  7$aMedicine and Nursing
700   $aDaniela D. Pollak$4auth$01318730
702   $aTimo Partonen$4auth
906   $aBOOK
912   $a9910346738003321
996   $aIntrinsic Clocks$93033495
997   $aUNINA