LEADER 00840nam a22002411i 4500 001 991003698019707536 005 20230315112558.0 008 040802s1927 sz |||||||||||||||||ger 035 $ab13113707-39ule_inst 035 $aARCHE-106631$9ExL 040 $aBibl. Interfacoltà T. Pellegrino$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a794.1 100 1 $aVoellmy, Erwin$080958 245 10$aSchachtaktik /$cErwin Voellmy 260 $aBasel :$bMajer,$c1927- 300 $av. ;$c21 cm 650 4$aScacchi 907 $a.b13113707$b02-04-14$c05-08-04 912 $a991003698019707536 945 $aLE002 Fondo Giudici S 685$g1$i2002000388803$lle002$nC. 1$o-$pE0.00$q-$rn$so$t0$u0$v0$w0$x0$y.i13748531$z05-08-04 996 $aSchachtaktik$9307901 997 $aUNISALENTO 998 $ale002$b05-08-04$cm$da$e-$fger$gsq$h0$i1 LEADER 03959nam 2200421z- 450 001 9910346737703321 005 20210212 035 $a(CKB)4920000000094337 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58049 035 $a(oapen)doab58049 035 $a(EXLCZ)994920000000094337 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRegulatory RNAs in the Nervous System, 2nd Edition 210 $cFrontiers Media SA$d2018 215 $a1 online resource (346 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-657-9 330 $aUntil about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential. 606 $aNeurosciences$2bicssc 610 $aaging 610 $abrain plasticity 610 $aneurodegeneration 610 $aneurodevelopment 610 $aneurodevelopmental disorder 610 $atranscriptomics 615 7$aNeurosciences 700 $aTommaso Pizzorusso$4auth$01326357 702 $aLaure Bally-Cuif$4auth 702 $aAlessandro Cellerino$4auth 906 $aBOOK 912 $a9910346737703321 996 $aRegulatory RNAs in the Nervous System, 2nd Edition$93037372 997 $aUNINA