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035   $a(CKB)4920000000094360
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53425
035   $a(EXLCZ)994920000000094360
100   $a20202102d2018      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMicroglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
210   $cFrontiers Media SA$d2018
215   $a1 electronic resource (327 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-525-4 
330   $aMicroglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson?s disease (PD), Alzheimer?s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington?s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization.
610   $aM2 Microglia
610   $aMicroglial Polarization
610   $aNeurodegenerative diseases
610   $aM1 Microglia
610   $aAging
610   $aNeuroinflammation
610   $aM1/M2 Switch
700   $aIsidre Ferrer$4auth$01331919
702   $aYu Tang$4auth
906   $aBOOK
912   $a9910346735003321
996   $aMicroglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases$93040651
997   $aUNINA