LEADER 02281nam 2200493 450 001 9910346732703321 005 20231027212101.0 010 $a1-83962-200-8 010 $a1-83962-199-0 035 $a(CKB)4920000000094383 035 $a(NjHacI)994920000000094383 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40610 035 $a(MiAaPQ)EBC30390279 035 $a(Au-PeEL)EBL30390279 035 $a(EXLCZ)994920000000094383 100 $a20221017d2019 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAldosterone-Mineralocorticoid Receptor $eCell Biology to Translational Medicine /$fBrian Harvey, Frederic Jaisser, editors 205 $a1st ed. 210 $cIntechOpen$d2019 210 1$aLondon :$cIntechOpen,$d[2019] 210 4$dİ2019 215 $a1 online resource (300 pages) $cillustrations 311 $a1-83962-198-2 320 $aIncludes bibliographical references and index. 330 $aThis book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation. 606 $aAldosterone$xPhysiological effect 610 $aMedicine 610 $aEndocrinology 610 $aHealth Sciences 615 0$aAldosterone$xPhysiological effect. 676 $a615.364 702 $aHarvey$b Brian 702 $aJaisser$b Frederic 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910346732703321 996 $aAldosterone-Mineralocorticoid Receptor$93386093 997 $aUNINA