LEADER 03566nam 2200541 a 450 001 9910781798603321 005 20230725050835.0 010 $a0-309-21107-7 010 $a1-283-21343-5 010 $a9786613213433 010 $a0-309-21105-0 035 $a(CKB)2550000000042938 035 $a(EBL)3378803 035 $a(MiAaPQ)EBC3378803 035 $a(Au-PeEL)EBL3378803 035 $a(CaPaEBR)ebr10488624 035 $a(CaONFJC)MIL321343 035 $a(OCoLC)923283637 035 $a(EXLCZ)992550000000042938 100 $a20110827d2011 uy 0 101 0 $aeng 135 $aurcn||||||||| 200 10$aGenerating evidence for genomic diagnostic test development$b[electronic resource] $eworkshop Summary /$fTheresa Wizemann and Adam C. Berger, rapporteurs ; Roundtable on translating Genomic-Based Research for Health, Board on Health Sciences Policy, Institute of Medicine of the National Academies 210 $aWashington, D.C. $cNational Academies Press$d2011 215 $a1 online resource (100 p.) 300 $aDescription based upon print version of record. 311 $a0-309-21104-2 320 $aIncludes bibliographical references. 327 $a""Front Matter""; ""Reviewers""; ""Acknowledgments""; ""Contents""; ""Tables, Figures, and Boxes""; ""Abbreviations and Acronyms""; ""1 Introduction""; ""2 Stakeholder Perspectives on Evidence""; ""3 Approaches to Evidence Generation""; ""4 Overcoming Barriers for Evidence Generation""; ""5 Considerations Moving Forward""; ""6 Final Remarks""; ""References""; ""Appendix A: Workshop Agenda""; ""Appendix B: Speaker Biographical Sketches""; ""Appendix C: Registered Attendees"" 330 $a"Ten years after the sequencing of the human genome, scientists have developed genetic tests that can predict a person's response to certain drugs, estimate the risk of developing Alzheimer's disease, and make other predictions based on known links between genes and diseases. However, genetic tests have yet to become a routine part of medical care, in part because there is not enough evidence to show they help improve patients' health.The Institute of Medicine (IOM) held a workshop to explore how researchers can gather better evidence more efficiently on the clinical utility of genetic tests. Generating Evidence for Genomic Diagnostic Test Development compares the evidence that is required for decisions regarding clearance, use, and reimbursement, to the evidence that is currently generated. The report also addresses innovative and efficient ways to generate high-quality evidence, as well as barriers to generating this evidence. Generating Evidence for Genomic Diagnostic Test Development contains information that will be of great value to regulators and policymakers, payers, health-care providers, researchers, funders, and evidence-based review groups."--Publisher's description. 606 $aGenomics 606 $aDiagnosis 606 $aGene mapping 615 0$aGenomics. 615 0$aDiagnosis. 615 0$aGene mapping. 676 $a616.0420027 701 $aWizemann$b Theresa M$0890630 701 $aBerger$b Adam C$01120088 712 02$aInstitute of Medicine (U.S.).$bRoundtable on Translating Genomic-Based Research for Health. 712 02$aInstitute of Medicine (U.S.).$bBoard on Health Sciences Policy. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910781798603321 996 $aGenerating evidence for genomic diagnostic test development$93817256 997 $aUNINA LEADER 01899nam 2200445z- 450 001 9910346700703321 005 20210211 035 $a(CKB)4920000000094687 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/51937 035 $a(oapen)doab51937 035 $a(EXLCZ)994920000000094687 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aLocal Investigation of Single Magnetic Molecules with Scanning Tunneling Microscopy 210 $cKIT Scientific Publishing$d2018 215 $a1 online resource (II, 128 p. p.) 225 1 $aExperimental Condensed Matter Physics / Karlsruher Institut für Technologie, Physikalisches Institut 311 08$a3-7315-0819-2 330 $aWe worked on different magnetic molecules containing 3d and 4f magnetic centers. Their growth on metallic surfaces, topographies, spin states, magnetic properties and electron transport were locally investigated by using scanning tunneling microscopy (STM) at temperatures down to 30mK. The main achievement of this dissertation reveals the abrupt switching of crystal fields during formation of molecular contacts. 606 $aPhysics$2bicssc 610 $aeinzelnes magnetisches Moleku?l 610 $ainelastic excitation 610 $amolecular contact 610 $amolekularer Kontakt 610 $aRastertunnelmikroskopie 610 $ascanning tunneling microscopy 610 $asingle magnetic molecule 610 $aspin state 610 $aSpinzustand 610 $aunelastische Erregung 615 7$aPhysics 700 $aChen$b Jinjie$4auth$01296315 906 $aBOOK 912 $a9910346700703321 996 $aLocal Investigation of Single Magnetic Molecules with Scanning Tunneling Microscopy$93023992 997 $aUNINA