LEADER 04204nam 22010453a 450 001 9910346689303321 005 20250203235432.0 010 $a9783038978954 010 $a3038978957 024 8 $a10.3390/books978-3-03897-895-4 035 $a(CKB)4920000000094776 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59479 035 $a(ScCtBLL)65f04698-4784-46f2-9644-efe58e35a742 035 $a(OCoLC)1117887350 035 $a(oapen)doab59479 035 $a(EXLCZ)994920000000094776 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSmart Nanovesicles for Drug Targeting and Delivery$fCarlotta Marianecci, Maria Carafa 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (198 p.) 311 08$a9783038978947 311 08$a3038978949 330 $aNanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action. The drug/contrast agent-containing vesicles need to be directed to precise locations within the body to obtain desired magnitude and duration of the therapeutic or diagnostic effect. This spatial control in the delivery might open new avenues to modulate drug activity while avoiding side-effects and to optimize contrast agent properties while avoiding a broad distribution in the organism. However, delivering and targeting active substances into specific tissues and cells is still a challenge in designing novel therapeutic approaches against untreatable disorders, such as tumors and degenerative diseases. 606 $aMedicine and Nursing$2bicssc 610 $aprotein corona 610 $abuspirone 610 $adrug delivery 610 $aPlectranthus ecklonii 610 $aantiproliferative activity 610 $apancreatic ductal adenocarcinoma 610 $atetraethyl orthosilicate 610 $acancer therapy 610 $ananoparticles 610 $acationic liposomes 610 $aIbuprofen 610 $aSBA-15 610 $agastrointestinal stability 610 $amesoporous silica nanoparticles 610 $aParvifloron D 610 $aanti-tumor drugs 610 $aliposomes 610 $agingiva mesenchymal stromal cells 610 $asoy lecithin liposomes 610 $aMCM-41 610 $alipophilic compound 610 $amultifunctional liposomes 610 $acaryophyllene sesquiterpene 610 $adrug loading 610 $alamellarity 610 $ahCMEC/D3 cells 610 $agold shell 610 $amagnetic/plasmonic nanoparticles 610 $apH-sensitive niosomes 610 $ahot flushes 610 $anasal delivery system 610 $aandrographolide 610 $abrain delivery 610 $apancreatic cancer 610 $aPain 610 $aexosomes 610 $aNSAIDs 610 $afreeze-drying 610 $amanganese ferrite 610 $asurfactant 610 $acytotoxicity 610 $apaclitaxel 610 $aovariectomized rat 610 $aPAMPA 610 $auptake and safety 610 $ananovesicular nasal carrier 610 $aStober's synthesis 610 $aAnalgesia 610 $aprotocells 610 $ananocochleates 610 $asquamous cell carcinoma 615 7$aMedicine and Nursing 700 $aMarianecci$b Carlotta$01302831 702 $aCarafa$b Maria 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910346689303321 996 $aSmart Nanovesicles for Drug Targeting and Delivery$93026667 997 $aUNINA