LEADER 04075nam 2201009z- 450 001 9910346689103321 005 20231214133648.0 010 $a3-03921-164-1 035 $a(CKB)4920000000094778 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53322 035 $a(EXLCZ)994920000000094778 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMethods in Computational Biology 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (214 p.) 311 $a3-03921-163-3 330 $aModern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics data. A primary goal of this Special Issue, entitled ?Methods in Computational Biology?, is the communication of computational biology methods, which can extract biological design principles from complex data sets, described in enough detail to permit the reproduction of the results. This issue integrates interdisciplinary researchers such as biologists, computer scientists, engineers, and mathematicians to advance biological systems analysis. The Special Issue contains the following sections:?Reviews of Computational Methods?Computational Analysis of Biological Dynamics: From Molecular to Cellular to Tissue/Consortia Levels?The Interface of Biotic and Abiotic Processes?Processing of Large Data Sets for Enhanced Analysis?Parameter Optimization and Measurement 610 $ainosine 610 $aimmune checkpoint inhibitor 610 $ageometric singular perturbation theory 610 $asimulation 610 $aBioModels Database 610 $aADAR 610 $acalcium current 610 $abifurcation analysis 610 $abacterial biofilms 610 $anonlinear dynamics 610 $aexplanatory model 610 $aturning point bifurcation 610 $aoscillator 610 $aworkflow 610 $abioreactor integrated modeling 610 $amodeling methods 610 $aelementary flux modes visualization 610 $amultiscale systems biology 610 $aevolutionary algorithm 610 $ametabolic model 610 $adifferential evolution 610 $areduced-order model 610 $acomputational model 610 $agut microbiota dysbiosis 610 $acanard-induced EADs 610 $acomputational biology 610 $ametabolic modelling 610 $amethods 610 $aSREBP-2 610 $amechanistic model 610 $asystems modeling 610 $abiological networks 610 $amacromolecular composition 610 $aprovenance 610 $aflux balance analysis 610 $aimmunotherapy 610 $acompartmental modeling 610 $aimmuno-oncology 610 $ametabolic network visualization 610 $amechanism 610 $abistable switch 610 $aClostridium difficile infection 610 $abioreactor operation optimization 610 $amicroRNA targeting 610 $aCFD simulation 610 $abiomass reaction 610 $aRNA editing 610 $aordinary differential equation 610 $ametabolic modeling 610 $amass-action networks 610 $ahybrid model 610 $amultiple time scales 610 $aquantitative systems pharmacology (QSP) 610 $amathematical modeling 610 $amicroRNA 610 $acancer 610 $aparameter optimization 610 $aHopf bifurcation 610 $abreast 700 $aCarlson$b Ross$4auth$01318727 702 $aSauro$b Herbert$4auth 906 $aBOOK 912 $a9910346689103321 996 $aMethods in Computational Biology$93033491 997 $aUNINA