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Impact of Surge Vessels -- Practical Considerations for Continuous Drug Substance Manufacturing -- Continuous Crystallization: Equipment and Operation -- Continuous Feeding-Blending in Pharmaceutical Continuous Manufacturing -- Recent Progress in Roll Compaction Process Development for Pharmaceutical Solid Dosage Form Manufacture -- Continuous wet granulation processes -- Fluidized Bed Drying -- Statistical Methods in Quality by Design and Process Analytical Technologies for continuous processes to enable real-time release -- Active Process Control in Pharmaceutical Continuous Manufacturing-The Quality by Control (QbC) Paradigm -- Real-time Optimization in Pharmaceutical Manufacturing -- Safety Guidelines for Continuous Chemistry Experimental Work in the Laboratory -- Evaluating the Busieness/Supply Chain Benefits of Continuous Processing in Pharmaceuticals -- Regulatory Considerations for Continuous Manufacturing. 330 $aContinuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuous manufacturing, applications of continuous flow chemistry in drug synthesis, continuous crystallization, continuous drying, feeders and blenders, roll compaction and continuous wet granulation.The underlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PAT) for continuous processing, process control strategies including new concepts of quality-by-control (QbC), real-time process management and plant optimization, business and supply chain considerations related to continuous manufacturing as well as safety guidelines related to continuous chemistry. A separate chapter is dedicated to discussing regulatory aspects of continuous manufacturing, with description of current regulatory environment quality/GMP aspects, as well as regulatory gaps and challenges. Our aim from publishing this book is to make it a valuable reference for readers interested in this topic, with a desire to gain a fundamental understanding of engineering principles and mechanistic studies utilized in understanding and developing continuous processes. 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