LEADER 04168 am 2200769 n 450 001 9910315242503321 005 20150922 010 $a2-84788-717-2 010 $a2-84788-716-4 024 7 $a10.4000/books.enseditions.4252 035 $a(CKB)3710000000579894 035 $a(FrMaCLE)OB-enseditions-4252 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53088 035 $a(PPN)189314052 035 $a(EXLCZ)993710000000579894 100 $a20150929j|||||||| ||| 0 101 0 $afre 135 $auu||||||m|||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 13$aLe Même et l'Ordre $eMichel Foucault et le savoir à l'âge classique /$fPhilippe Sabot 210 $aLyon $cENS Éditions$d2015 215 $a1 online resource (174 p.) 311 $a2-84788-715-6 330 $aDans Les mots et les choses (1966), Michel Foucault accorde une place centrale à l?analyse de la disposition archéologique du savoir classique. Le présent ouvrage s?attache à expliciter les principaux enjeux de cette analyse, en montrant qu?elle renvoie au fond à une double interrogation. De quelle pensée du Même l?épistémè de l?âge classique relève-t-elle?? Et comment cette pensée du Même en vient-elle à organiser la mise en ordre des choses dans des savoirs positifs (grammaire générale, histoire naturelle, analyse des richesses) qui s?élaborent eux-mêmes suivant les contraintes épistémologiques fortes d?une nomenclature et d?une taxinomie?? La première interrogation engage clairement le statut philosophique d?une archéologie du savoir de l?âge classique. La seconde implique en outre, pour l?archéologue, une manière de travailler et de penser à partir de l?archive discursive d?une époque. Le livre de Philippe Sabot s?efforce ainsi de rendre compte de cette double dimension de l?analyse archéologique de Foucault en attirant l?attention à la fois sur l?effort de systématisation dont relève une telle analyse et sur le traitement particulier qu?elle propose des archives du savoir. In The Order of Things (1966), Michel Foucault focuses on the analysis of the archeological configuration of classical knowledge. This book aims to clarify the main issues of such an analysis and shows how it refers to a double question. On what sort of « thought of the Same » does the classical épistémè depend ? And how does this « thought of the Same » manage to organize the implementation of things in positive knowledge (general grammar, natural history, analysis of wealth) under the dual constraint of a classification and a taxonomy ? The first question concerns obviously the philosophical status of an archeology of classical knowledge. The second one additionnally involves for the archeologist a way of working and thinking from the discursive archive of an epoch. Philippe Sabot?s? 517 $aMême et l'Ordre 517 $aMEME ET L'ORDRE. MICHEL FOUCAULT ET LE SAVOIR A L'AGE CLASSIQUE 517 $aLE MEME ET L'ORDRE. MICHEL FOUCAULT ET LE SAVOIR A L'AGE CLASSIQUE 606 $aArchaeology 606 $aHistory 606 $asavoir 606 $aarchive 606 $aâge classique 606 $aordre 606 $amême 606 $aconnaissance 606 $aFoucault (Michel) 606 $aLes mots et les choses 606 $aknowledge 606 $aclassical age 606 $aorder 606 $asame 610 $aclassical age 610 $asame 610 $aknowledge 610 $aorder 615 4$aArchaeology 615 4$aHistory 615 4$asavoir 615 4$aarchive 615 4$aâge classique 615 4$aordre 615 4$amême 615 4$aconnaissance 615 4$aFoucault (Michel) 615 4$aLes mots et les choses 615 4$aknowledge 615 4$aclassical age 615 4$aorder 615 4$asame 700 $aSabot$b Philippe$0755953 801 0$bFR-FrMaCLE 906 $aBOOK 912 $a9910315242503321 996 $aLe Même et l'Ordre$93039870 997 $aUNINA LEADER 05361nam 22015613a 450 001 9910346684303321 005 20250203235429.0 010 $a9783039210619 010 $a3039210610 024 8 $a10.3390/books978-3-03921-061-9 035 $a(CKB)4920000000094826 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54029 035 $a(ScCtBLL)9b5b364c-2670-4301-9845-c4b9a0365ea7 035 $a(OCoLC)1117844310 035 $a(oapen)doab54029 035 $a(EXLCZ)994920000000094826 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$amTOR in Human Diseases$fOlivier Dormond 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (480 p.) 311 08$a9783039210602 311 08$a3039210602 330 $aThe mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. 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