LEADER 02753nam 22004813a 450 001 9910346668603321 005 20250203235437.0 010 $a9783038972495 010 $a3038972495 024 8 $a10.3390/books978-3-03897-249-5 035 $a(CKB)4920000000094981 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58457 035 $a(ScCtBLL)0c0ec300-9c1b-4468-8311-7bbfdac6df12 035 $a(OCoLC)1163847789 035 $a(oapen)doab58457 035 $a(EXLCZ)994920000000094981 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRibosome Inactivating Toxins$fDaniel Gillet, Julien Barbier 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (329 p.) 311 08$a9783038972488 311 08$a3038972487 330 $aRibosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses.This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs. 606 $aMedicine$2bicssc 610 $atoxin 610 $aShiga toxin 610 $aricin 610 $aRibosome inactivating protein 615 7$aMedicine 700 $aGillet$b Daniel$01786817 702 $aBarbier$b Julien 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910346668603321 996 $aRibosome Inactivating Toxins$94319010 997 $aUNINA