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010   $a3-03897-249-5
035   $a(CKB)4920000000094981
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58457
035   $a(EXLCZ)994920000000094981
100   $a20202102d2019      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aRibosome Inactivating Toxins
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
215   $a1 electronic resource (329 p.)
311   $a3-03897-248-7 
330   $aRibosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses. This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs.
610   $atoxin
610   $aShiga toxin
610   $aricin
610   $aRibosome inactivating protein
700   $aDaniel Gillet (Ed.)$4auth$01280385
702   $aJulien Barbier (Ed.)$4auth
906   $aBOOK
912   $a9910346668603321
996   $aRibosome Inactivating Toxins$93016857
997   $aUNINA