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035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48213
035   $a(EXLCZ)994920000000095018
100   $a20202102d2019      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aFungal Pathogenesis in Humans: The Growing Threat
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
215   $a1 electronic resource (232 p.)
311   $a3-03897-900-7 
330   $aCancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunistic fungal infections are probably the deadliest threat to these patients due to their difficult early diagnosis, the limited effect of antifungal drugs and the appearance of resistances. In recent years, a considerable effort has been devoted to investigating the role of many virulence traits in the pathogenic outcome of fungal infections. New virulence factors (hypoxia adaptation, CO2 sensing, pH regulation, micronutrient acquisition, secondary metabolites, immunity regulators, etc.) have been reported and their molecular mechanisms of action are being thoroughly investigated. The recent application of gene-editing technologies such as CRISPr-Cas9, has opened a whole new window to the discovery of new fungal virulence factors. Accurate fungal genotyping, Next Generation Sequencing and RNAseq approaches will undoubtedly provide new clues to interpret the plethora of molecular interactions controlling these complex systems. Unraveling their intimate regulatory details will provide insights for a more target-focused search or a rational design of more specific antifungal agents. This Special Issue is show significant discoveries, proofs of concept of new theories or relevant observations in fungal pathogenesis and its regulation.
517   $aFungal Pathogenesis in Humans
610   $aCO2 sensing
610   $aMicronutrient acquisition
610   $aBiofilm formation
610   $aSecondary metabolites and toxins
610   $aCriptococcus
610   $aFungal virulence
610   $aImmune evasion
610   $apH regulation
610   $aPneumocysits
610   $aAspergillus
610   $aRegulation of antifungals resistance
610   $aCandida
610   $aFusarium
610   $aTrehalose biosynthesis
610   $aFungal genotyping
610   $aScedosporium
700   $aLeal$b Fernando$4auth$01206496
906   $aBOOK
912   $a9910346664903321
996   $aFungal Pathogenesis in Humans: The Growing Threat$93022187
997   $aUNINA