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010   $a9783038975557
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024 8 $a10.3390/books978-3-03897-555-7
035   $a(CKB)4920000000095037
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61394
035   $a(ScCtBLL)78649cb4-ce14-40cd-a410-57b0e8012b59
035   $a(OCoLC)1163810166
035   $a(oapen)doab61394
035   $a(EXLCZ)994920000000095037
100   $a20250203i20192019  uu 
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 04$aThe Tumor Microenvironment of High Grade Serous Ovarian Cancer$fKenneth P. Nephew, Anirban Mitra, M. Sharon Stack, Joanna E. Burdette
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2019
210  1$aBasel, Switzerland :$cMDPI,$d2019.
215   $a1 electronic resource (434 p.)
311 08$a9783038975540 
311 08$a3038975540 
330   $aThe Special Issue on high grade serous ovarian cancer (HGSOC) and the contribution of the tumor microenviroment (TME) consists of reviews contributed by leaders in the OC field. As HGSOC metastases have a highly complex TME, there is an urgent need to better understand the TME in general, its distinct components in particular, and the role of the TME in the context of disease recurrence and development of chemoresistance. The Special Issue incorporates the current understanding of the different parts of thd TME components, including the cancer cells themselves, the cells surrounding the cancer cells or stromal cells, and the cells of the immune system, which are attracted to the site of metastases.  In addition to these cells of the TME, the role of various cellular factors  made by the cells of the TME are also  the subject of the reviews. In addition, reviews in this Special Issue cover the complex relationships between the molecular mechanisms of HGSOC progression, including genomic, epigenomic and transcriptomic changes and changes in the immune cell landscape, as these may provide attractive new molecular targets for HGSOC therapy.
606   $aBiology, life sciences$2bicssc
610   $aovarian cancer
610   $atranscriptomic
610   $astroma
610   $aimmune cells
610   $aepigenetics
610   $arecurrence
610   $aimmunotherapies
610   $achemoresistance
610   $afibroblasts
610   $ametastasis
610   $agenomic
610   $atumor microenvironment
610   $acancer stem cells
615  7$aBiology, life sciences
700   $aNephew$b Kenneth P$01787396
702   $aMitra$b Anirban
702   $aStack$b M. Sharon
702   $aBurdette$b Joanna E
801  0$bScCtBLL
801  1$bScCtBLL
906   $aBOOK
912   $a9910346663003321
996   $aThe Tumor Microenvironment of High Grade Serous Ovarian Cancer$94320812
997   $aUNINA