LEADER 06729nam 2202017z- 450 001 9910346661103321 005 20210211 035 $a(CKB)4920000000095056 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54549 035 $a(oapen)doab54549 035 $a(EXLCZ)994920000000095056 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNew Advances on Zika Virus Research 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (552 p.) 311 08$a3-03897-764-0 330 $aZika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders-including fetal microcephaly and Guillain-Barre? syndrome in adults-have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus-host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis. 606 $aMedicine and Nursing$2bicssc 610 $aAedes aegypti 610 $aAfrican-lineage 610 $aanti-viral immunity 610 $aantiviral 610 $aantiviral compounds 610 $aantiviral responses 610 $aantivirals 610 $aapoptosis 610 $aarbovirus 610 $aAsian lineage 610 $aAsian-lineage 610 $aassay standardization 610 $aastrocytomas 610 $abacterial artificial chromosome 610 $aBacterial artificial chromosome 610 $aBayesian analyses 610 $ablood-retinal barrier 610 $aboolean logic-processing nucleic acid probes 610 $acell surface receptors 610 $achimeric viruses 610 $aclinical trials 610 $acongenital Zika syndrome 610 $across-reactions 610 $acryptic promoter silencing 610 $acytopathic effects 610 $adengue virus 610 $adengue viruses 610 $adetoxification and immune system responses 610 $adiagnosis 610 $adsRNA 610 $aeIF4A 610 $aELISA 610 $aemerging arbovirus 610 $aEQA 610 $aexternal quality assessment 610 $aeye 610 $afetal infection 610 $aflavivirus 610 $aflaviviruses 610 $aFSS13025 610 $aFull-length cDNA infectious clones 610 $afull-length molecular clone 610 $agene expression 610 $agenetic variability 610 $aheme-oxygenase 1 610 $ahepatocytes 610 $ahost genetic variation 610 $ahost-directed antivirals 610 $ahuman brain glial cells 610 $aIgA 610 $aIgG avidity tests 610 $aimmune response 610 $aindirect immunofluorescence 610 $ainfection 610 $ainfectious cDNA 610 $ainfectious clone 610 $ainfectious RNA 610 $ainnate response 610 $ainsecticide resistance 610 $aisothermal nucleic acid amplification 610 $alaboratory preparedness 610 $amicrocephaly 610 $amicroglia cells 610 $amicroRNAs 610 $amicrosphere immunoassay 610 $amolecular diagnostics 610 $amonoclonal antibodies 610 $amosquito 610 $amosquito surveillance 610 $amosquito-borne flavivirus 610 $aMR766 610 $amultiplex nucleic acid detection 610 $amutagenesis 610 $anatural history 610 $aneural cells 610 $aneural progenitor cells 610 $aneuroinflammation 610 $aneurons 610 $aneuropathogenesis 610 $aNHP 610 $aNon-human primates 610 $aNS1 protein 610 $aNS2A protein 610 $aNS5 610 $anucleic acid computation 610 $anucleic acid strand exchange 610 $aocular 610 $aoptimised 610 $aoutbreak control 610 $aplacenta cells 610 $aplaque reduction neutralization test 610 $aplasmid toxicity 610 $apoint-of-care diagnostics 610 $apolymerase chain reaction 610 $apregnancy 610 $aprM-E proteins 610 $aprostate 610 $aQCMD 610 $areplication 610 $areplicon 610 $areporter virus 610 $aresearch models and tools 610 $areverse genetics 610 $arhesus macaques 610 $aRNA-seq 610 $asecondary infections 610 $aserology 610 $asexual transmission 610 $asilvestrol 610 $asiRNA 610 $asubgenomic replicon 610 $atestes 610 $atesticular cells 610 $atestis 610 $aTet-inducible 610 $atherapeutics 610 $atherapy 610 $aTLR7/8 610 $atype I IFN antagonist 610 $avaccines 610 $avalidated 610 $aviral counteraction 610 $aviral evolution 610 $aviral fitness 610 $aviral genetic variation 610 $aviral pathogenesis 610 $aviral pathogenicity 610 $aviral permissiveness 610 $aviral persistence 610 $aviral replication 610 $aviral survival 610 $avirus attachment 610 $avirus like particles 610 $aZika 610 $azika virus 610 $aZika virus 610 $aZika virus (ZIKV) 610 $aZiks virus 610 $aZIKV 610 $aZIKV-associated neurologic disorders 610 $aZIKV-host interactions 615 7$aMedicine and Nursing 700 $aMartinez-Sobrido$b Luis$4auth$01311265 702 $aAlmazan Toral$b Fernando$4auth 906 $aBOOK 912 $a9910346661103321 996 $aNew Advances on Zika Virus Research$93030072 997 $aUNINA