LEADER 06637nam 2201981z- 450 001 9910346661103321 005 20231214133555.0 035 $a(CKB)4920000000095056 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54549 035 $a(EXLCZ)994920000000095056 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNew Advances on Zika Virus Research 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 electronic resource (552 p.) 311 $a3-03897-764-0 330 $aZika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders?including fetal microcephaly and Guillain-Barré syndrome in adults?have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus?host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis. 610 $amicroRNAs 610 $aantivirals 610 $areverse genetics 610 $anucleic acid computation 610 $aviral pathogenesis 610 $aplaque reduction neutralization test 610 $aclinical trials 610 $aviral genetic variation 610 $aviral fitness 610 $apregnancy 610 $atype I IFN antagonist 610 $aprM-E proteins 610 $aeye 610 $areplicon 610 $aantiviral responses 610 $aBacterial artificial chromosome 610 $agene expression 610 $aNS1 protein 610 $aviral permissiveness 610 $aZIKV?host interactions 610 $areporter virus 610 $aviral persistence 610 $ablood-retinal barrier 610 $avirus like particles 610 $aemerging arbovirus 610 $aNon-human primates 610 $aheme-oxygenase 1 610 $amosquito surveillance 610 $aantiviral compounds 610 $aZIKV-associated neurologic disorders 610 $aexternal quality assessment 610 $aoutbreak control 610 $atherapeutics 610 $acryptic promoter silencing 610 $atestis 610 $aneurons 610 $amutagenesis 610 $aRNA-seq 610 $amicrosphere immunoassay 610 $ahost-directed antivirals 610 $amolecular diagnostics 610 $aBayesian analyses 610 $aastrocytomas 610 $aFull-length cDNA infectious clones 610 $aviral pathogenicity 610 $aneural progenitor cells 610 $afull-length molecular clone 610 $aantiviral 610 $amultiplex nucleic acid detection 610 $aAsian-lineage 610 $anucleic acid strand exchange 610 $aIgA 610 $aAfrican-lineage 610 $avaccines 610 $aZika 610 $aresearch models and tools 610 $aimmune response 610 $aIgG avidity tests 610 $apolymerase chain reaction 610 $aAsian lineage 610 $asexual transmission 610 $aTLR7/8 610 $aneuropathogenesis 610 $across-reactions 610 $agenetic variability 610 $amosquito 610 $aZIKV 610 $ainfectious cDNA 610 $aprostate 610 $ahost genetic variation 610 $amonoclonal antibodies 610 $aoptimised 610 $aanti-viral immunity 610 $aQCMD 610 $aarbovirus 610 $aFSS13025 610 $aMR766 610 $aNS5 610 $aEQA 610 $atesticular cells 610 $avirus attachment 610 $aflavivirus 610 $amosquito-borne flavivirus 610 $adsRNA 610 $aboolean logic-processing nucleic acid probes 610 $aZiks virus 610 $aviral replication 610 $aAedes aegypti 610 $ainfection 610 $anatural history 610 $ainfectious RNA 610 $azika virus 610 $achimeric viruses 610 $asubgenomic replicon 610 $areplication 610 $ahuman brain glial cells 610 $amicroglia cells 610 $ahepatocytes 610 $abacterial artificial chromosome 610 $adetoxification and immune system responses 610 $atestes 610 $adengue viruses 610 $aZika virus 610 $ainsecticide resistance 610 $aNS2A protein 610 $aplasmid toxicity 610 $acell surface receptors 610 $aserology 610 $aviral evolution 610 $alaboratory preparedness 610 $aflaviviruses 610 $aTet-inducible 610 $adengue virus 610 $adiagnosis 610 $aassay standardization 610 $ainfectious clone 610 $aELISA 610 $ainnate response 610 $acongenital Zika syndrome 610 $asecondary infections 610 $aapoptosis 610 $aviral survival 610 $aocular 610 $avalidated 610 $arhesus macaques 610 $aneuroinflammation 610 $aplacenta cells 610 $aNHP 610 $aZika virus (ZIKV) 610 $apoint-of-care diagnostics 610 $aisothermal nucleic acid amplification 610 $amicrocephaly 610 $acytopathic effects 610 $aindirect immunofluorescence 610 $afetal infection 610 $atherapy 610 $asiRNA 610 $aviral counteraction 610 $aneural cells 610 $asilvestrol 610 $aeIF4A 700 $aMartinez-Sobrido$b Luis$4auth$01311265 702 $aAlmazan Toral$b Fernando$4auth 906 $aBOOK 912 $a9910346661103321 996 $aNew Advances on Zika Virus Research$93030072 997 $aUNINA