LEADER 03614nam 2200409z- 450 001 9910345965403321 005 20231214132851.0 035 $a(CKB)4920000000094060 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55137 035 $a(EXLCZ)994920000000094060 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOcular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders 210 $cFrontiers Media SA$d2018 215 $a1 electronic resource (247 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-563-7 330 $aEye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles.

The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features.

The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows:

1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis.

2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks. 610 $agenetic 610 $atremor 610 $aimmune 610 $abasal ganglia 610 $aataxia 610 $anystagmus 610 $aparkinson 610 $adegenerative 610 $acerebellum 700 $aAasef G. Shaikh$4auth$01284059 702 $aAlessandra Rufa$4auth 906 $aBOOK 912 $a9910345965403321 996 $aOcular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders$93019245 997 $aUNINA