LEADER 02019nam 2200337Ia 450 001 996391894903316 005 20210104162135.0 035 $a(CKB)1000000000678270 035 $a(EEBO)2248525086 035 $a(OCoLC)ocm61297125e 035 $a(OCoLC)61297125 035 $a(EXLCZ)991000000000678270 100 $a20050819d1642 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 00$aNew propositions$b[electronic resource] /$fpropounded by the Earle of Pembrook, the Earle of Northumberland, the Earle of Essex, and the Earle of Holland ; to the Lord Major, aldermen, and Common Councell of the city in Guild Hall, on Saturday being the 11 day of June, 1642 ; in the behalfe of all the Commons in England ; whereunto is annexed many remarkeable passages with the numbers of horse that they have underwrit ; together with the substance of a letter sent from Holland ; wherein is declared that there are many hundreds of carbines, 3000 great saddles, 300 barrels of powder, 8 pieces of ordnance which is conceived to be bought with part of the money borrowed upon the jewels of the crowne, and to be transported to England ; also a declaration from both Houses of Parliament concerning the ordering of the militia, directed to the deputy lievtenants of the respective counties throughout all England and Dominion of Wales 210 $aLondon $cPrinted by T. Fawcet$dJune 13, 1642 215 $a[8] p 300 $aReproduction of original in Thomason Collection, British Library. 330 $aeebo-0098 607 $aGreat Britain$xHistory$yCharles I, 1625-1649 701 $aEssex$b Robert Devereux$cEarl of,$f1591-1646.$01001097 701 $aHolland$b Henry Rich$cEarl of,$f1590-1649.$01002122 701 $aNorthumberland$b Algernon Percy$cEarl of,$f1602-1668.$01002123 701 $aPembroke$b Philip Herbert$cEarl of,$f1584-1650.$01002124 801 0$bUMI 801 1$bUMI 906 $aBOOK 912 $a996391894903316 996 $aNew propositions$92300034 997 $aUNISA LEADER 03342nam 2200517z- 450 001 9910345964003321 005 20210212 035 $a(CKB)4920000000094074 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58603 035 $a(oapen)doab58603 035 $a(EXLCZ)994920000000094074 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function 210 $cFrontiers Media SA$d2018 215 $a1 online resource (152 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-385-5 330 $aGenetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks.The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. 517 $aRole of Protein-Protein Interactions in Metabolism 606 $aPharmacology$2bicssc 610 $aBiocatalysis 610 $aCytochrome P450 610 $aDrug metabolism 610 $aMembrane-associated progesterone receptor 610 $aPharmacogenetics 610 $aPOR 610 $aPXR 610 $aSteroids 610 $aUDP-glucuronosyltransferase 610 $aUGT 615 7$aPharmacology 700 $aMichel Kranendonk$4auth$01281234 702 $aWayne L. Backes$4auth 702 $aUlrich M. Zanger$4auth 702 $aAmit V. Pandey$4auth 702 $aColin J. Henderson$4auth 702 $aYuji Ishii$4auth 906 $aBOOK 912 $a9910345964003321 996 $aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function$93018404 997 $aUNINA