LEADER 03342nam  2200517z- 450 
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035   $a(CKB)4920000000094074
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58603
035   $a(oapen)doab58603
035   $a(EXLCZ)994920000000094074
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function
210   $cFrontiers Media SA$d2018
215   $a1 online resource (152 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-385-5 
330   $aGenetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks.The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease.
517   $aRole of Protein-Protein Interactions in Metabolism
606   $aPharmacology$2bicssc
610   $aBiocatalysis
610   $aCytochrome P450
610   $aDrug metabolism
610   $aMembrane-associated progesterone receptor
610   $aPharmacogenetics
610   $aPOR
610   $aPXR
610   $aSteroids
610   $aUDP-glucuronosyltransferase
610   $aUGT
615  7$aPharmacology
700   $aMichel Kranendonk$4auth$01281234
702   $aWayne L. Backes$4auth
702   $aUlrich M. Zanger$4auth
702   $aAmit V. Pandey$4auth
702   $aColin J. Henderson$4auth
702   $aYuji Ishii$4auth
906   $aBOOK
912   $a9910345964003321
996   $aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function$93018404
997   $aUNINA