LEADER 00911cam0-22003011i-450 001 990005478360403321 005 20220824083844.0 035 $a000547836 035 $aFED01000547836 035 $a(Aleph)000547836FED01 035 $a000547836 100 $a19990604d1966----km-y0itay50------ba 101 0 $aeng 102 $aGB 105 $af-------001yy 200 1 $a<>sanctuary of Hemithea at Kastabos$fby J. M. Cook and W. H. Plommer 210 $aCambridge$cThe University Press$d1966 215 $aXIII, 179 p., 3 tav.$d26 cm 700 1$aCook,$bJohn Manuel$f<1910-1994>$045899 701 1$aPlommer,$bW.H.$0397382 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990005478360403321 952 $aARCH. G 117 8$bARCH. 12877$fFLFBC 952 $aST.REL. 09-C 20$bST.REL. 242$fFLFBC 959 $aFLFBC 996 $aSanctuary of Hemithea at Kastabos$9587471 997 $aUNINA LEADER 04346nam 2200481z- 450 001 9910345963903321 005 20231214133303.0 035 $a(CKB)4920000000094075 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58604 035 $a(EXLCZ)994920000000094075 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition 210 $cFrontiers Media SA$d2018 215 $a1 electronic resource (152 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-491-6 330 $aGenetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: ? Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. ? Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. ? Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. ? Structural implications of mutations and polymorphisms on protein-protein interactions. ? Functional characterization of protein-protein interactions. ? Analysis of protein-protein interaction networks in health and disease. ? Regulatory mechanisms governing metabolic processes based on protein-protein interactions. ? Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms. 517 $aRole of Protein-Protein Interactions in Metabolism 610 $aPOR 610 $aPharmacogenetics 610 $aUGT 610 $aBiocatalysis 610 $aUDP-glucuronosyltransferase 610 $aCytochrome P450 610 $aDrug metabolism 610 $aMembrane-associated progesterone receptor 610 $aPXR 610 $aSteroids 700 $aMichel Kranendonk$4auth$01281234 702 $aWayne L. Backes$4auth 702 $aUlrich M. Zanger$4auth 702 $aAmit V. Pandey$4auth 702 $aColin J. Henderson$4auth 702 $aYuji Ishii$4auth 906 $aBOOK 912 $a9910345963903321 996 $aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition$93039402 997 $aUNINA