LEADER 03092nam  2200421z- 450 
001 9910345963803321
005 20210211
035   $a(CKB)4920000000094076
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54349
035   $a(oapen)doab54349
035   $a(EXLCZ)994920000000094076
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aNatural Antibodies in Health and Disease
210   $cFrontiers Media SA$d2018
215   $a1 online resource (180 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-405-3 
330   $aNatural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to 'neo-self' carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
606   $aMedicine and Nursing$2bicssc
610   $aAntibodies
610   $aB cells
610   $aB-1 cells
610   $aIgM
610   $aimmunoglobulin
610   $ainnate immunity
610   $anatural antibodies
615  7$aMedicine and Nursing
700   $aAna Maria Hernandez$4auth$01305932
702   $aNichol E. Holodick$4auth
906   $aBOOK
912   $a9910345963803321
996   $aNatural Antibodies in Health and Disease$93028033
997   $aUNINA