LEADER 02476nam 2200457z- 450 001 9910345963303321 005 20210211 035 $a(CKB)4920000000094081 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56871 035 $a(oapen)doab56871 035 $a(EXLCZ)994920000000094081 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPrecision Medicine in Oncology 210 $cFrontiers Media SA$d2019 215 $a1 online resource (163 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-705-2 330 $aThe emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration. 606 $aMedicine and Nursing$2bicssc 610 $aaberration 610 $acomputational biology 610 $ain vivo preclinical platform 610 $anoncoding RNA 610 $aoncology 610 $apathology 610 $aprecision medicine 610 $asynthetic biology 615 7$aMedicine and Nursing 700 $aAndrea Lunardi$4auth$01292333 702 $aAngela Re$4auth 702 $aCaterina Nardella$4auth 702 $aAlessandro Quattrone$4auth 906 $aBOOK 912 $a9910345963303321 996 $aPrecision Medicine in Oncology$93022182 997 $aUNINA