LEADER 02616nam  2200469z- 450 
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035   $a(CKB)4920000000094085
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54024
035   $a(oapen)doab54024
035   $a(EXLCZ)994920000000094085
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMR Spectroscopy in Neuropsychiatry
210   $cFrontiers Media SA$d2018
215   $a1 online resource (90 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-524-6 
330   $aNeuropsychiatric disorders, covering both psychotic and depressive disorders, but also autism and attention-deficit hyperactivity disorder (ADHD), are characterized by abnormal behavior and brain structure. Accumulating evidence suggests that altered neurochemistry plays a role in these disorders and may have a causal relationship with the observed behavioral and structural abnormalities. To improve the understanding of neurochemical anomalies and (patho)physiological changes in psychiatric conditions, in vivo assessment of the affected tissue, the brain, is wanted and needed. Magnetic resonance spectroscopy (MRS) is a non-invasive technique which allows in vivo assessment of the molecular composition of brain tissues and identification of metabolites involved in physiological and pathological processes, which is otherwise virtually impossible. Only in the last decade with the development of high field MR methodologies, MRS has become sensitive enough for broader use in clinical studies. The implications are many, but proper guidance and elucidation of the pros and cons for the specific methods is needed to optimally exploit the potential. This Research Topic updates the reader on the possibilities and pitfalls of MRS today and highlights methodologies and applications for the future.
606   $aMedicine$2bicssc
610   $a7 Tesla MRI
610   $aFunctional MRS
610   $aGABA
610   $aGlutamate
610   $aMR spectroscopy
610   $aNeurochemistry
610   $aNeuroimaging
610   $aPsychiatry
610   $aSchizophrenia
615  7$aMedicine
700   $aAlice Egerton$4auth$01311568
702   $aHulshoff Pol$b Hilleke$f1962-$4auth
702   $aAnouk Marsman$4auth
702   $aBrian V. Broberg$4auth
906   $aBOOK
912   $a9910345962903321
996   $aMR Spectroscopy in Neuropsychiatry$93030430
997   $aUNINA