LEADER 02978nam  2200409z- 450 
001 9910345961603321
005 20210211
035   $a(CKB)4920000000094098
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/49982
035   $a(oapen)doab49982
035   $a(EXLCZ)994920000000094098
100   $a20202102d2018      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aImmune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing
210   $cFrontiers Media SA$d2018
215   $a1 online resource (159 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-618-8 
330   $a80% of the bodies' immune cells are harbored within the intestine. They are only separated from 1014 microorganisms by a single layer of intestinal epithelial cells and a secreted superficial mucus layer. Therefore, the intestinal epithelial surface represents a main frontier in host defense. Providing an intact mucosal barrier is vital for the host to limit bacterial entry and spread to the circulation. This specialized localization requires dynamic responses of intestinal epithelial cells to both pathogen- and immune-derived signals. Moreover, emergency barriers are needed in the setting of epithelial damage, which allow provisional microbial control and a timely restitution of mucosal integrity. Epithelial cells constantly interact with subjacent immune cells and fibroblasts, actively directing the immune response and also shaping the luminal microbiota. Epithelial dysfunction has been appreciated in recent years as a driving element in the pathogenesis of Inflammatory Bowel Diseases (IBD). Additionally, primary immune deficiencies may manifest in the form of chronic intestinal inflammation mimicking features of IBD. Recent advances in the techniques of epithelial cell culture and the discovery of new immune cell types and cellular properties have tremendously advanced the understanding in this interesting field of research. In this research topic, we want to focus on the complex interaction of intestinal epithelial cells, luminal flora and adjacent immune cells and invite manuscripts which highlight the dynamic responses of both epithelium and immune cells under steady-state or inflammatory conditions, and envision how this may be translated to the benefit of patient-care.
606   $aMedicine$2bicssc
610   $aimmune system
610   $ainflammatory bowel diseases
610   $aintestinal epithelium
610   $alymphocytes
610   $amucosal immunity
615  7$aMedicine
700   $aBritta Siegmund$4auth$01311566
702   $aMoritz Leppkes$4auth
702   $aChristoph Becker$4auth
906   $aBOOK
912   $a9910345961603321
996   $aImmune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing$93030428
997   $aUNINA