LEADER 04643nam 22007455 450 001 9910337955903321 005 20251113175251.0 010 $a3-030-11488-0 024 7 $a10.1007/978-3-030-11488-6 035 $a(CKB)4100000008339194 035 $a(MiAaPQ)EBC5781090 035 $a(DE-He213)978-3-030-11488-6 035 $a(PPN)236519859 035 $a(EXLCZ)994100000008339194 100 $a20190528d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBioactive Lipids in Health and Disease /$fedited by Andres Trostchansky, Homero Rubbo 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (193 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1127 311 08$a3-030-11487-2 327 $aPrelims -- Diffusion and transport of reactive species across cell membranes -- Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry. Understanding Peroxisome Proliferator-Activated Receptors: from the structure to the regulatory actions on metabolism -- Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase. Unfolded protein response: Cause or consequence of lipid and lipoprotein metabolism disturbances?- Arachidonic acid metabolism in macrophages: role of NADPH oxidases -- Lipid Metabolism and Signaling in Platelet Function -- Dyslipidemia in ischemia/reperfusion injury -- Epicardial adipose tissue in cardiovascular disease -- Bioactive Lipids and the gut-brain axis: diet as a modulator of bioactivity and diversity of lipids in the brain -- Nitroalkylation of ?-synuclein by nitro-oleic acid: Implications for Parkinsonīs disease -- Bioactive lipids in inflammation after central nervous system injury -- Index. 330 $aThe purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1127 606 $aMedical genetics 606 $aHuman physiology 606 $aNeurochemistry 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aProteins 606 $aCardiovascular system 606 $aPhysiology 606 $aMedical Genetics 606 $aHuman Physiology 606 $aNeurochemistry 606 $aBiomedical Research 606 $aProtein Biochemistry 606 $aCardiovascular Physiology 615 0$aMedical genetics. 615 0$aHuman physiology. 615 0$aNeurochemistry. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aProteins. 615 0$aCardiovascular system. 615 0$aPhysiology. 615 14$aMedical Genetics. 615 24$aHuman Physiology. 615 24$aNeurochemistry. 615 24$aBiomedical Research. 615 24$aProtein Biochemistry. 615 24$aCardiovascular Physiology. 676 $a612.01577 676 $a599.935 702 $aTrostchansky$b Andres$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRubbo$b Homero$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337955903321 996 $aBioactive Lipids in Health and Disease$92224721 997 $aUNINA