LEADER 01208nam--2200409---450 001 990003387910203316 005 20210729143504.0 035 $a000338791 035 $aUSA01000338791 035 $a(ALEPH)000338791USA01 035 $a000338791 100 $a20100415d1998----km-y0itay50------ba 101 $aita 102 $aIT 105 $a||||||||001yy 200 1 $a<> amici per Nando$eGiornata di studi in onore di Fernando Ferrara$fa cura di Lidia Curti e Laura Di Michele 210 $aNapoli$cs.n.$d1998 215 $aXIII, 386 p. : 1 ritr.$c24 cm 225 2 $aApophoreta$v3 300 $aTenuta a Napoli nel 1997 410 0$12001$aApophoreta 454 1$12001 461 1$1001-------$12001 606 0 $aFerrara, Fernando 702 1$aCURTI,$bLidia 702 $aDI MICHELE,$bLaura 710 12$aGiornata di studi in onore di Fernando Ferrara$e$0607396 801 0$aIT$bsalbc$gISBD 912 $a990003387910203316 951 $aVII.2.8$b4460 DSLL 951 $aVI.7.B. 2269$bISLA$cVI.7$d545604 959 $aBK 969 $aISLA 969 $aDSLL 979 $aDSLL$b90$c20100415$lUSA01$h1403 996 $aAmici per Nando$91127321 997 $aUNISA LEADER 04305nam 22006015 450 001 9910337949603321 005 20200706013801.0 010 $a3-030-04278-2 024 7 $a10.1007/978-3-030-04278-3 035 $a(CKB)4100000007522429 035 $a(MiAaPQ)EBC5637236 035 $a(DE-He213)978-3-030-04278-3 035 $a(PPN)233796169 035 $a(EXLCZ)994100000007522429 100 $a20190116d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCholesterol Modulation of Protein Function $eSterol Specificity and Indirect Mechanisms /$fedited by Avia Rosenhouse-Dantsker, Anna N. Bukiya 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (200 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1115 311 $a3-030-04277-4 327 $aPart 1. Sterol specificity in modulating protein function: 1. Chirality effect on cholesterol modulation of protein function -- 2. A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs -- 3. Regulation of BK channel activity by cholesterol and its derivatives -- 4. Chiral specificity of cholesterol orientation within cholesterol binding sites in inwardly rectifying potassium channels -- Part 2. Indirect modulation of protein function by cholesterol: 5. Cholesterol effect on the physical properties of lipid membranes -- 6. Effect of cholesterol on the dipole potential of lipid membranes -- 7. Mass spectroscopy imaging of cholesterol -- 8. Cholesterol-dependent gating effects on ion channels. 330 $aIn this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1115 606 $aProteomics 606 $aProteins 606 $aCell membranes 606 $aMolecular biology 606 $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aProteomics. 615 0$aProteins. 615 0$aCell membranes. 615 0$aMolecular biology. 615 14$aProteomics. 615 24$aProtein Science. 615 24$aMembrane Biology. 615 24$aMolecular Medicine. 676 $a612.0153 676 $a572.5795 702 $aRosenhouse-Dantsker$b Avia$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBukiya$b Anna N$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337949603321 996 $aCholesterol Modulation of Protein Function$92079138 997 $aUNINA