LEADER 03406oam 2200493 450 001 9910137088203321 005 20230621141059.0 010 $a9782889196623 (ebook) 035 $a(CKB)3710000000824755 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42865 035 $a(EXLCZ)993710000000824755 100 $a20191103c2015uuuu uu | 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular and phenotypic plasticity in cancer$b[electronic resource] /$fedited by Petranel Theresa Ferrao, Andreas Behren, Robin Andersonand Erik Thompson 210 $cFrontiers Media SA$d2015 210 1$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (77 pages) $cillustrations 225 1 $aFrontiers Research Topics 320 $aIncludes bibliographical references. 330 $aThe process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies. 606 $aCancer 610 $acrosstalk 610 $aImmune System 610 $aPhenotype-switching 610 $aplasticity 610 $aExosomes 610 $aEMT 610 $aTherapy-resistance 610 $asignalling 610 $aheterogeneity 610 $aCancer 615 0$aCancer 700 $aPetranel Theresa Ferrao$4auth$01365478 702 $aAndreas Behren$4auth 702 $aErik Thompson$4auth 702 $aRobin Anderson$4auth 801 0$bUkMaJRU 912 $a9910137088203321 996 $aCellular and phenotypic plasticity in cancer$93387417 997 $aUNINA LEADER 05143nam 22006615 450 001 9910337947403321 005 20200630050704.0 010 $a3-030-16546-9 024 7 $a10.1007/978-3-030-16546-8 035 $a(CKB)4100000008403496 035 $a(MiAaPQ)EBC5786724 035 $a(DE-He213)978-3-030-16546-8 035 $a(PPN)248603841 035 $a(EXLCZ)994100000008403496 100 $a20190607d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEssential Oil Research $eTrends in Biosynthesis, Analytics, Industrial Applications and Biotechnological Production /$fedited by Sonia Malik 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (450 pages) 311 $a3-030-16545-0 327 $aPreface -- Part 1. Essential oils composition and why plants produce them -- Chapter 1. Essential oils -- Chapter 2. Factors influencing the production and chemical composition of essential oil in aromatic plants from Brazil -- Chapter 3. Hedychium Essential Oils: Composition and Uses -- Chapter 4. The Essential Oils of the Burseraceae -- Part 2. Uses of essential oils in various industries -- Chapter 5. Essential oil of betel leaf (Piper betle L.): A novel addition to the world food sector -- Chapter 6. Artemisia annua and A. afra essential oils and their therapeutic potential -- Chapter 7. Outstanding Efficacy of Essential Oils Against Oral Pathogens -- Chapter 8. Chemical diversity and insecticidal and anti-tick activities of essential oils of plants from Northeast Brazil -- Part 3. Extraction and Bioanalytical Techniques -- Chapter 9. Adulteration Analysis in Essential Oils -- Chapter 10. Essential Oils from Pines: Chemistry and Applications -- Part 4. Strategies and Technologies for Essential Oil Production -- Chapter 11. Biotechnological approaches to increase essential oil yield and quality in aromatic plants: the Lavandula latifolia (Spike lavender) example. Past and recommendations for the future -- Chapter 12. The phytochemical composition, biological effects, and biotechnological pproaches to the production of high value essential oil from geranium -- Chapter 13. Biotechnological production of aromatic oils from plants -- Chapter 14. The role of biotechnology in essential oils production from non-herbaceous plants -- Chapter 15. Eremothecium oil biotechnology as a novel technology for the modern essential oil production -- Index. 330 $aThis book highlights the advances in essential oil research, from the plant physiology perspective to large-scale production, including bioanalytical methods and industrial applications. The book is divided into 4 sections. The first one is focused on essential oil composition and why plants produce these compounds that have been used by humans since ancient times. Part 2 presents an update on the use of essential oils in various areas, including food and pharma industries as well as agriculture. In part 3 readers will find new trends in bioanalytical methods. Lastly, part 4 presents a number of approaches to increase essential oil production, such as in vitro and hairy root culture, metabolic engineering and biotechnology. Altogether, this volume offers a comprehensive look at what researchers have been doing over the last years to better understand these compounds and how to explore them for the benefit of the society. 606 $aBotanical chemistry 606 $aPlant physiology 606 $aNatural resources 606 $aPlant breeding 606 $aPharmaceutical technology 606 $aPharmaceutical chemistry 606 $aPlant Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14021 606 $aPlant Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33020 606 $aNatural Resources$3https://scigraph.springernature.com/ontologies/product-market-codes/U39000 606 $aPlant Breeding/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/L24060 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 615 0$aBotanical chemistry. 615 0$aPlant physiology. 615 0$aNatural resources. 615 0$aPlant breeding. 615 0$aPharmaceutical technology. 615 0$aPharmaceutical chemistry. 615 14$aPlant Biochemistry. 615 24$aPlant Physiology. 615 24$aNatural Resources. 615 24$aPlant Breeding/Biotechnology. 615 24$aPharmaceutical Sciences/Technology. 615 24$aMedicinal Chemistry. 676 $a363.7394 676 $a661.806 702 $aMalik$b Sonia$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337947403321 996 $aEssential Oil Research$92079135 997 $aUNINA