LEADER 03663nam 22005175 450 001 9910337946203321 005 20200630062210.0 010 $a3-030-11135-0 024 7 $a10.1007/978-3-030-11135-9 035 $a(CKB)4100000008154060 035 $a(MiAaPQ)EBC5771836 035 $a(DE-He213)978-3-030-11135-9 035 $a(PPN)236523333 035 $a(EXLCZ)994100000008154060 100 $a20190509d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIn Vitro Neuronal Networks $eFrom Culturing Methods to Neuro-Technological Applications /$fedited by Michela Chiappalone, Valentina Pasquale, Monica Frega 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (387 pages) 225 1 $aAdvances in Neurobiology,$x2190-5215 ;$v22 311 $a3-030-11134-2 327 $a1. Past, present and future of neuronal models in vitro -- 2. In vitro models of neural disorders -- 3. Neuronal cultures and nanomaterials -- 4. Advances in Human Stem Cell Derived Neuronal Cell Culturing and Analysis -- 5. Large scale, high-resolution microelectrode arrays for interrogation of neurons and networks -- 6. Multi-site intracellular recordings -- 7. From MEAs to MOAs: the next generation of bioelectronic interfaces for neuronal cultures -- 8. Scaling spike detection and sorting for next generation electrophysiology -- 9. Burst detection methods -- 10. Reconstruction of functional connectivity from multi-electrode recordings and calcium imaging -- 11. Open-source tools for processing and analysis of in vitro extracellular neuronal signals -- 12. Screening chemicals for potential neurotoxicity and developmental neurotoxicity using neural networks grown on MEAs -- 13. Long-term activity dynamics of single neurons and networks -- 14. Electrical and optical closed-loop systems. 330 $aThis book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies. 410 0$aAdvances in Neurobiology,$x2190-5215 ;$v22 606 $aNeurochemistry 606 $aBiomedical engineering 606 $aNeurochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/B18010 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 615 0$aNeurochemistry. 615 0$aBiomedical engineering. 615 14$aNeurochemistry. 615 24$aBiomedical Engineering/Biotechnology. 676 $a612.82 676 $a573.85 702 $aChiappalone$b Michela$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPasquale$b Valentina$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aFrega$b Monica$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337946203321 996 $aIn Vitro Neuronal Networks$91945688 997 $aUNINA