LEADER 04624nam 2200601 450 001 9910133694103321 005 20230213215339.0 010 $a1-118-79391-9 010 $a1-118-79392-7 035 $a(CKB)3280000000033630 035 $a(EBL)1887752 035 $a(SSID)ssj0000951315 035 $a(PQKBManifestationID)11603810 035 $a(PQKBTitleCode)TC0000951315 035 $a(PQKBWorkID)10893241 035 $a(PQKB)10898223 035 $a(MiAaPQ)EBC1887752 035 $a(Au-PeEL)EBL1887752 035 $a(CaPaEBR)ebr10997612 035 $a(OCoLC)894581169 035 $a(EXLCZ)993280000000033630 100 $a20150108h19831983 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClinical trials $ea practical approach /$fStuart J. Pocock 210 1$aChichester, England :$cJohn Wiley & Sons,$d1983. 210 4$d©1983 215 $a1 online resource (280 p.) 225 0 $aA Wiley medical publication Clinical trials 300 $aDescription based upon print version of record. 311 1 $a0-471-96883-8 311 1 $a0-471-90155-5 320 $aIncludes bibliographical references and index. 327 $aCover; Title Page; Contents; Preface; 1. Introduction: The Rationale of Clinical Trials; 1.1 Types of clinical trial; 1.2 Controlled clinical trials and the scientific method; 1.3 An example of a clinical trial for primary breast cancer; 2. The Historical Development of Clinical Trials; 2.1 Clinical trials before 1950; 2.2 Clinical trials since 1950; 2.3 Cancer chemotherapy in the United States; 2.4 Treatment of acute myocardial infarction; 2.5 The pharmaceutical industry; 3. Organization and Planning; 3.1 The protocol; 3.2 Administration, staff and finance; 3.3 Selection of patients 327 $a3.4 Treatment schedules 3.5 Evaluation of patient response; 4. The Justification for Randomized Controlled Trials; 4.1 Problems with uncontrolled trials; 4.2 Problems with historical controls; 4.3 Problems with concurrent non-randomized controls; 4.4 Is randomization feasible?; 5. Methods of Randomization; 5.1 Patient registration; 5.2 Preparing the randomization list; 5.3 Stratified randomization; 5.4 Unequal randomization; 6. Blinding and Placebos; 6.1 The justification for double-blind trials; 6.2 The conduct of double-blind trials; 6.3 When is blinding feasible?; 7. Ethical Issues 327 $a7.1 Medical progress and individual patient care 7.2 Informed patient consent; 8. Crossover Trials; 8.1 Within-patient comparisons; 8.2 The two-period crossover design; 8.3 The analysis and interpretation of crossover trials; 8.4 Multi-period crossover designs; 9. The Size of a Clinical Trial; 9.1 Statistical methods for determining trial size; 9.2 The realistic assessment of trial size; 9.3 The inadequacy of small trials; 9.4 Multi-centre trials; 9.5 The number of treatments and factorial designs; 10. Monitoring Trial Progress; 10.1 Reasons for monitoring; 10.2 Interim analyses 327 $a10.3 Repeated significance testing: group sequential designs 10.4 Continuous sequential designs; 11. Forms and Data Management; 11.1 Form design; 11.2 Data management; 11.3 The use of computers; 12. Protocol Deviations; 12.1 Ineligible patients; 12.2 Non-compliance and incomplete evaluation; 12.3 Inclusion of withdrawals in analysis; 13. Basic Principles of Statistical Analysis; 13.1 Describing the data; 13.2 Significance tests; 13.3 Estimation and confidence limits; 14. Further Aspects of Data Analysis; 14.1 Prognostic factors; 14.2 The analysis of survival data; 14.3 Multiplicity of data 327 $a15. Publication and Interpretation of Findings 15.1 Trial reports and their critical evaluation; 15.2 An excess of false-positives; 15.3 Combining evidence and overall strategy; References; Index 330 $aThis comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience. 606 $aClinical trials 615 0$aClinical trials. 676 $a615/.7/0724 700 $aPocock$b Stuart J.$0519288 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910133694103321 996 $aClinical trials$951093 997 $aUNINA LEADER 01450nam a2200289 i 4500 001 991002919249707536 008 071009s2005 sz b 001 0 fre d 020 $a2600010521 020 $a9782600010528 035 $ab13602482-39ule_inst 040 $aDip.to Studi Giuridici$bita 245 00$aCitoyenneté et participation à la basse époque hellénistique :$bactes de la table ronde des 22 et 23 mai 2004, Paris BNF ... /$cédités par Pierre Fröhlich et Christel Müller 260 $aGenève :$bDroz,$c2005 300 $a310 p. ;$c22 cm 440 0$aÉcole pratique des hautes études, Sciences historiques et philologiques.$nIIII$pHautes études du monde gréco-romain ;$v35 504 $aCon bibliografia 650 04$aCittadinanza$zGrecia antica$xStoria$ySec. II a.C.$vCongressi 650 04$aPartecipazione politica$zGrecia antica$xStoria$ySec. II a.C.$vCongressi 651 4$aGrecia antica$xPolitica e governo$xStoria$ySec. II a.C.$vCongressi 700 1 $aFröhlich, Pierre$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0622241 700 1 $aMüller, Christel,$d1965- 907 $a.b13602482$b02-04-14$c09-10-07 912 $a991002919249707536 945 $aLE027 R-XXII 172$g1$i2027000135738$lle027$o-$pE94.50$q-$rl$s- $t0$u0$v0$w0$x0$y.i14576119$z09-10-07 996 $aCitoyenneté et participation à la basse époque hellénistique$91463534 997 $aUNISALENTO 998 $ale027$b09-10-07$cm$da $e-$ffre$gsz $h0$i0 LEADER 03766nam 22005775 450 001 9910337749403321 005 20230810164413.0 010 $a9783030148652 010 $a3030148653 024 7 $a10.1007/978-3-030-14865-2 035 $a(CKB)4100000008153972 035 $a(MiAaPQ)EBC5771565 035 $a(DE-He213)978-3-030-14865-2 035 $a(EXLCZ)994100000008153972 100 $a20190509d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNational Subcommissions of ICMI and their Role in the Reform of Mathematics Education /$fedited by Alexander Karp 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (255 pages) 225 1 $aInternational Studies in the History of Mathematics and its Teaching,$x2524-8030 311 08$a9783030148645 311 08$a3030148645 327 $aChapter 1. Challenges, hopes, actions and tensions in the early years of the International Commission on the Teaching of Mathematics -- chapter 2.The French Subcommission of the International Commission on Mathematical Instruction (1908-1914): Mathematicians committed to the renewal of school mathematics -- Chapter 3. The German IMUK subcommission -- Chapter 4. The British National Subcommission of ICMI and the Mathematics Education Reform -- Chapter 5.The Italian Subcommission of the International Commission on the Teaching of Mathematics (1908-1920). Organisational and Scientific contributions -- Chapter 6. The Russian National Subcommission of ICMI and the Mathematics Education Reform Movement -- Chapter 7. The American National Subcommission of ICMI. . 330 $aICMI (or IMUK) was founded in 1908 and initiated the establishment of national subcommissions to launch national activities in response to the IMUK agenda and to promote the reform proposals within each member country.While ICMI?s activities were thoroughly studied, the activities of the national subcommissions are studied only very marginally. In the meantime, their work has been of major importance ? both because of their role in exploring and documenting the development of mathematics education at the beginning of the 20th century, and because of the changes and new ideas which they brought to their countries. Importantly, even if some results of their activities were analyzed within their countries in the corresponding languages, almost nothing is known internationally. This book is planned to deepen our knowledge on at least some of the national subcommissions. 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