LEADER 06514nam 22006135 450 001 9910337603703321 005 20220203151244.0 010 $a3-319-71530-5 024 7 $a10.1007/978-3-319-71530-8 035 $a(CKB)4100000008962857 035 $a(DE-He213)978-3-319-71530-8 035 $a(PPN)238492907 035 $a(EXLCZ)994100000008962857 100 $a20190617d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTissue-Engineered Vascular Grafts$b[electronic resource] /$fedited by Beat Walpoth, Helga Bergmeister, Gary Bowlin, Deling Kong, Joris Rotmans, Peter Zilla 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 225 1 $aTissue Engineering and Regeneration 327 $a1. Clinical Aspects and Limitations of Vascular Grafts (Peter ZILLA, SA) -- 2. Synthetic Materials for Vascular Scaffolds.- 3. Mechanical Testing of Vascular Grafts (Christian GRASL and Martin STOIBER, Heinz SCHIMA, AU) --  4. In vitro Testing of Engineered Vascular Grafts.- 5. In Vivo Testing and Animal Models for Vascular Grafts (Helga BERGMEISTER, AU, Bruno PODESSER, AU) -- 6. Decellularized Vascular Grafts for VTE (Axel HAVERICH, Sotiris KOROSSIS, Andres HILFIKER, DE) -- 7. Degradable and Non-degradable Vascular Scaffolds (Yadong WANG, William WAGNER, USA) -- 8. In Vivo Vascular Tissue Engineering - Long-term Results (Beat WALPOTH, CH) -- 9. Cell-Assembled Extracellular Matrix for Building Vascular Grafts (Nicolas L?HEUREUX, FR) -- 10. Cell-based/Seeding of Vascular Grafts (David VORP, Justin Sol WEINBAUM, Darren G HASKETT, USA) --  11. Vascular Tissue Engineering: the role of 3-D printing (Ali KHADEMHOSSEINI, Yu Shrike ZHANG, USA) -- 12. Autologous Mandril-based VTE (Joris ROTMANS, NL) -- 13. The Role of Tropoelastin in VTE (Tony WEISS, AUS) -- 14. Vascular Grafts made of Cell Sheets.- 15. Vascular Tissue Engineering: Pathology, Mechanisms, and Translational Implications (Carlijn BOUTEN, NL, Fred SCHOEN, USA).- 16. Models to study cardiovascular calcification relevant to tissue engineering (Elena AIKAWA, USA).-  17. The incorporation and release of bioactive molecules in Vascular Grafts (Deling KONG, CN) -- 18. Functionalization/Coating of Vascular Grafts" including "cell surface interaction" (Olivier FELIX, Gero DECHER, FR, Mitsuru AKASHI, JP) -- 19. Clinical application of VTE for children (Toshi SHINOKA, Christopher BREUER, USA) -- 20. Bioengineered Human Acellular Vessels (Laura NIKLASON, Jeffrey H. LAWSON, USA). 330 $aCardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone.   Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery.   Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE.  All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications.   The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment.   Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences. 410 0$aTissue Engineering and Regeneration 606 $aBiomedical engineering 606 $aRegenerative medicine 606 $aTissue engineering 606 $aVascular surgery 606 $aBiomedical materials 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080 606 $aVascular Surgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H59133 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 615 0$aBiomedical engineering. 615 0$aRegenerative medicine. 615 0$aTissue engineering. 615 0$aVascular surgery. 615 0$aBiomedical materials. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aRegenerative Medicine/Tissue Engineering. 615 24$aVascular Surgery. 615 24$aBiomaterials. 676 $a610.28 702 $aWalpoth$b Beat$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBergmeister$b Helga$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBowlin$b Gary$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKong$b Deling$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRotmans$b Joris$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZilla$b Peter$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337603703321 996 $aTissue-Engineered Vascular Grafts$92505228 997 $aUNINA