LEADER 03506nam 22005415 450 001 9910337522903321 005 20200630042238.0 010 $a3-030-15111-5 024 7 $a10.1007/978-3-030-15111-9 035 $a(CKB)4100000008403508 035 $a(MiAaPQ)EBC5786738 035 $a(DE-He213)978-3-030-15111-9 035 $a(PPN)248603442 035 $a(EXLCZ)994100000008403508 100 $a20190606d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Biology of Senescence $eA Translational Approach /$fby Bernard Swynghedauw 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (127 pages) 225 1 $aPractical Issues in Geriatrics,$x2509-6060 311 $a3-030-15110-7 327 $a1. Introduction -- 2. The emerging medical landscape -- 3. Origins of ageing -- 4. The senescent cell -- 5. « Benign » clinical manifestations and their relationships with the senescent cell -- 6. Age-linked non transmissible diseases -- 7. The senescent cardiovascular system -- 8. « To treat» or prevent ageing -- 9. Senescence and darwinian evolution -- 10. Conclusions -- 11. Summary -- 12. Annexes -- 13. References. 330 $aThis book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for ?treating? it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related ?chronic non-transmissible diseases?), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to ?treat? or ?prevent? the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians. 410 0$aPractical Issues in Geriatrics,$x2509-6060 606 $aGeriatrics 606 $aGeneral practice (Medicine) 606 $aHuman genetics 606 $aGeriatrics/Gerontology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33150 606 $aGeneral Practice / Family Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H24003 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 615 0$aGeriatrics. 615 0$aGeneral practice (Medicine). 615 0$aHuman genetics. 615 14$aGeriatrics/Gerontology. 615 24$aGeneral Practice / Family Medicine. 615 24$aHuman Genetics. 676 $a305.26 676 $a571.878 700 $aSwynghedauw$b Bernard$4aut$4http://id.loc.gov/vocabulary/relators/aut$0782400 906 $aBOOK 912 $a9910337522903321 996 $aThe Biology of Senescence$92510888 997 $aUNINA