LEADER 03420nam 22005775 450 001 9910337514103321 005 20200701233404.0 010 $a3-319-98605-8 024 7 $a10.1007/978-3-319-98605-0 035 $a(CKB)4100000007656770 035 $a(DE-He213)978-3-319-98605-0 035 $a(MiAaPQ)EBC5923183 035 $a(PPN)23500636X 035 $a(EXLCZ)994100000007656770 100 $a20190213d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTextbook of Autoinflammation /$fedited by Philip J. Hashkes, Ronald M. Laxer, Anna Simon 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (X, 820 p. 154 illus., 135 illus. in color.) 311 $a3-319-98604-X 320 $aIncludes bibliographical references and index. 327 $aPart 1. Basic Science and Biology of Autoinflammation -- Part 2: Autoinflammatory Diseases -- Part 3: Integrative Cross Disease -- Part 4: Pharmacology and Therapies -- Part 5: Measurement and Data Analysis in Autoinflammatory Disease. 330 $aThis book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation. 606 $aRheumatology 606 $aPediatrics 606 $aImmunology 606 $aRheumatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33170 606 $aPediatrics$3https://scigraph.springernature.com/ontologies/product-market-codes/H49006 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aRheumatology. 615 0$aPediatrics. 615 0$aImmunology. 615 14$aRheumatology. 615 24$aPediatrics. 615 24$aImmunology. 676 $a616.978 702 $aHashkes$b Philip J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLaxer$b Ronald M$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSimon$b Anna$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910337514103321 996 $aTextbook of Autoinflammation$91736781 997 $aUNINA