LEADER 05292nam 22006135 450 001 9910337488203321 005 20250610110031.0 010 $a3-030-03934-X 024 7 $a10.1007/978-3-030-03934-9 035 $a(CKB)4100000008339436 035 $a(MiAaPQ)EBC5781532 035 $a(DE-He213)978-3-030-03934-9 035 $a(PPN)236523937 035 $a(MiAaPQ)EBC29093077 035 $a(EXLCZ)994100000008339436 100 $a20190529d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetics of Rare Autoimmune Diseases /$fedited by Javier Martín, Francisco David Carmona 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (244 pages) 225 1 $aRare Diseases of the Immune System,$x2282-6505 311 08$a3-030-03933-1 327 $aPreface -- I Connective tissue diseases -- 1 Systemic lupus erythematosus (Possible contributors: Maria Teruel & Marta Alarcón) -- 2 Systemic sclerosis (Possible contributors: Elena Lopez-Isac & Marialbert Acosta) -- 3 Behçet?s disease (Possible contributors: Lourdes Ortiz & Francisca Gonzalez-Ecribano) -- 4 Sjogren's síndrome (Possible contributors: Pers JO, Renaudineau Y. & Xavier Marriet) -- 5 Polymiositis/Dermatomyositis (Possible contributors: Ana Márquez & Albert Selva) -- II Autoimmune Vasculitis -- 6 ANCA-associated Vasculitis (Possible contributors: Augusto Vaglio) -- 7 Giant Cell Arteritis (Possible contributors: F. David Carmona & Miguel Ángel Gónzalez-Gay) -- 8 Takayasu?s Arteritis (Possible contributors: Amr H. Sawalha) -- 9 Kawasaki?s Disease (Possible contributors: David Burgner) -- III Gastrointestinal and Liver/hepatic Autoimmune Conditions -- 10 Primary Biliary Cirrhosis, Sclerosing Cholangitis, and Autoimmune Hepatitis (Possible contributors: G.J. Webb & G.M. Hirschfield) -- IV Central and Peripheral Nervous System -- 11 Multiple Sclerosis (Possible contributors: Antonio Alcina & Fuencisla Matesanz) -- 12 Myastenia Gravis (Possible contributors: Güher Saruhan Direskeneli) -- V Shared Gentetic Component -- 13 Common Genetic Component in Autoimmunity (Possible contributors: Alexandra Sasha) -- Subject Index. 330 $aThe main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet?s disease, Sjogren?s syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers. 410 0$aRare Diseases of the Immune System,$x2282-6505 606 $aRheumatology 606 $aImmunology 606 $aHepatology 606 $aHuman genetics 606 $aRheumatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33170 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aHepatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33088 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 615 0$aRheumatology. 615 0$aImmunology. 615 0$aHepatology. 615 0$aHuman genetics. 615 14$aRheumatology. 615 24$aImmunology. 615 24$aHepatology. 615 24$aHuman Genetics. 676 $a616.723 676 $a616.978 702 $aMartín$b Javier$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCarmona$b Francisco David$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337488203321 996 $aGenetics of Rare Autoimmune Diseases$91734967 997 $aUNINA LEADER 02996aam 2200373 n 450 001 9910874748903321 005 20250618102223 010 $a83-8142-519-0 035 $a(CKB)4100000011331859 035 $a(ceeol)ceeol871815 035 $a(CEEOL)871815 035 $a(EXLCZ)994100000011331859 100 $a20252218d2018 ||l | 101 0 $apol 200 1 $aSymmachia cesarstwa rzymskiego z Bogiem chrze?cijan (IV-VI wiek), t. 2. Jedna religia w jednym cesarstwie. Rzymscy imperatorzy sprzymierzeni z Bogiem na stra?y jedno?ci Ko?cio?a od Konstantyna I do Justyniana I. Byzantina Lodziensia XXXII$fS?awomir Bralewski 210 $a?ód? [Poland] $cWydawnictwo Uniwersytetu ?ódzkiego$d2018 215 $a1 online resource (1 p. 340) 225 $aUniwersytet ?ódzki 311 08$a83-8142-518-2 330 $aThe first volume of The Symmachia of the Roman Empire with the God of Christians (4th ? 6th Century), titled An Extraordinary Change: The Birth of a New Era, was devoted to reflections on the genesis of the alliance of the Roman Empire with the God of Christians as such and to the significant transformations that marked this breakthrough. In the second part, which is the present volume, the author deals with ecclesial institutions on the one hand and, on the other, rulers' efforts to maintain an alliance with God, which had been threatened, as they firmly believed, by various church splits epitomized by the great theological disputes like the Arian, Nestorian or Monophysite controversies. Professor S?awomir Bralewski?s work is undeniably important. This is a well-thought-out study, supported by the author's research in the field conducted over many years. It is therefore the fruit of his scientific maturity. The book is a concise, logical whole that offers a fair account, both substantive and bibliographic, of Polish and foreign achievements regarding the history of early Byzantium. On the one hand, the author's theses have the hallmarks of innovation, on the other, they are based on time-tested research methodology. They can therefore constitute an important and deep source of inspiration for further research. dr hab. Piotr Kochanek, prof. KUL The John Paul II Catholic University of Lublin 517 $aSymmachia cesarstwa rzymskiego z Bogiem chrzeÅ?cijan 517 $aSymmachia cesarstwa rzymskiego z Bogiem chrze?cijan 606 $aHistory 606 $aAncient World 615 0$aHistory 615 0$aAncient World 700 $aBralewski$b S?awomir$01825830 712 02$aCentral and Eastern European Online Library 801 0$bceeol 801 1$bceeol 906 $aBOOK 912 $a9910874748903321 996 $aSymmachia cesarstwa rzymskiego z Bogiem chrze?cijan (IV-VI wiek), t. 2. Jedna religia w jednym cesarstwie. Rzymscy imperatorzy sprzymierzeni z Bogiem na stra?y jedno?ci Ko?cio?a od Konstantyna I do Justyniana I. Byzantina Lodziensia XXXII$94393898 997 $aUNINA