LEADER 04318nam 22005895 450 001 9910337484103321 005 20200706080912.0 010 $a3-030-11446-5 024 7 $a10.1007/978-3-030-11446-6 035 $a(CKB)4100000008160595 035 $a(DE-He213)978-3-030-11446-6 035 $a(MiAaPQ)EBC5922857 035 $a(PPN)236524992 035 $a(EXLCZ)994100000008160595 100 $a20190513d2019 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiomarkers in Inflammatory Bowel Diseases /$fedited by Nik Sheng Ding, Peter De Cruz 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019. 215 $a1 online resource (XVII, 365 p. 35 illus., 30 illus. in color.) 311 $a3-030-11445-7 327 $aPart I: Introduction -- nflammatory bowel disease ? more than meets the eye - Clinical risk factors ? lessons from epidemiology -- Clinical trial design for biomarker discovery -- Database/ big data meets real world -- Patient reported outcomes -- Part II: Biomarkers ? Prognostic vs Predictive -- Biomarkers for remote monitoring -- Disease modification -- Part IIV: Crohn?s disease -- Luminal Crohn?s disease-. Perianal CD -- Fibrosis/ strictures in CD -- Post-op Crohn?s disease -- Part IV: Ulcerative colitis -- UC surveillance -- Acute severe UC -- Chronic active UC -- Pouchitis -- Refractory proctitis -- Feacal microbiota transplantation -- Primary sclerosing cholangitis -- Extraintestinal manifestations of IBD -- Part V: Specialised scenarios -- Pregnancy -- Nutrition -- TDM -- Biomarkers to quantify immune response -- Drug toxicity -- Part VI:Scientific -- Exposome and diet -- Microbiota -- Metabonomics -- Immunology -- Genomics -- Systems Biology in Biomarker research -- Part VII: Ideal tools for investigation in the future. 330 $aThis book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future. 606 $aGastroenterology  606 $aMicrobial genetics 606 $aMicrobial genomics 606 $aProteomics 606 $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061 606 $aMicrobial Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32010 606 $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X 615 0$aGastroenterology . 615 0$aMicrobial genetics. 615 0$aMicrobial genomics. 615 0$aProteomics. 615 14$aGastroenterology. 615 24$aMicrobial Genetics and Genomics. 615 24$aProteomics. 676 $a616.33 676 $a616.344 702 $aSheng Ding$b Nik$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDe Cruz$b Peter$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910337484103321 996 $aBiomarkers in Inflammatory Bowel Diseases$91736069 997 $aUNINA