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001 9910337483703321
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010   $a3-030-05517-5
024 7 $a10.1007/978-3-030-05517-2
035   $a(CKB)4100000008103772
035   $a(MiAaPQ)EBC5771198
035   $a(DE-He213)978-3-030-05517-2
035   $a(PPN)236524909
035   $a(EXLCZ)994100000008103772
100   $a20190503d2019      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDiagnosis and Management of Mitochondrial Disorders /$fedited by Michelangelo Mancuso, Thomas Klopstock
205   $a1st ed. 2019.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2019.
215   $a1 online resource (382 pages)
311   $a3-030-05516-7 
320   $aIncludes bibliographical references.
327   $aMitochondrial Medicine: an Historical Point of View,- Mitochondrial Biology and Function -- Mitochondrial Genetics -- Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS Syndrome) -- Myoclonic Epilepsy with Ragged Red Fibers (MERRF Syndrome) -- Leber Hereditary Optic Neuropathy (LHON) -- Progressive External Ophthalmoplegia (PEO) -- Leigh Syndrome -- Mitochondrial Depletion Syndromes -- Mitochondrial Neurogastrointestinal Encephalopathy (MNGIE) -- Mitochondrial Neurodegenerative Disorders I: Dementia and Parkinsonisms -- Mitochondrial Neurodegenerative Disorders II: Ataxia & Dystonia, Leukidystrophies -- Mitochondria & Heart -- Mitochondria & Liver -- Mitochondria & Respiratory Involvement -- Mitochondrial Endocrinology -- Diagnostic Approach to Mitochondrial Disease -- Mitochondrial Replacement Approaches -- Exercise/Training -- Mitochondrial Symptomatic Treatments -- Experimental Therapies.
330   $aThis book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world?s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
606   $aNeurology
606   $aHuman genetics
606   $aInternal medicine
606   $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002
615  0$aNeurology.
615  0$aHuman genetics.
615  0$aInternal medicine.
615 14$aNeurology.
615 24$aHuman Genetics.
615 24$aInternal Medicine.
676   $a572.869
676   $a616.07
702   $aMancuso$b Michelangelo$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aKlopstock$b Thomas$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910337483703321
996   $aDiagnosis and Management of Mitochondrial Disorders$91737513
997   $aUNINA