LEADER 04684nam 22006255 450 001 9910337481903321 005 20250610110034.0 010 $a3-030-04861-6 024 7 $a10.1007/978-3-030-04861-7 035 $a(CKB)4100000008103789 035 $a(MiAaPQ)EBC5776184 035 $a(DE-He213)978-3-030-04861-7 035 $a(PPN)23652304X 035 $a(MiAaPQ)EBC29093127 035 $a(EXLCZ)994100000008103789 100 $a20190502d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGastric Cancer In The Precision Medicine Era $eDiagnosis and Therapy /$fedited by Vincenzo Canzonieri, Antonio Giordano 205 $a1st ed. 2019. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2019. 215 $a1 online resource (262 pages) 225 1 $aCurrent Clinical Pathology,$x2197-781X 300 $aIncludes index. 311 08$a3-030-04860-8 327 $aGastric Tumorigenesis: Role of Inflammation and Helicobacter Pylori -- Genetic and Epigenetic Mechanisms in Gastric Cancer -- Diagnosis and Surveillance: Endoscopic Hallmarks -- Pathological Diagnosis And Classification Of Gastric Epithelial Tumors -- Diagnostic, Prognostic, Predictive and Therapeutic Tissue Biomarkers in Gastric Cancer -- Serum Biomarkers in Gastric Cancer -- New Agents in the treatment of Advanced Gastric Cancer: Targeted Therapy and Immunotherapy -- Combined-Modality Treatment for Locally Advanced Gastric Cancer: Current Evidences and New Perspectives -- Surgical Strategies in Gastric Cancer -- From Molecular Classification to Targeted Therapy for Gastric Cancer in the Precision Medicine Era -- Non-Coding RNA in Gastric Cancer with Potential Prognostic and Predictive Role -- Immunomodulation and Immunotherapy for Gastric Cancer -- Nanomedicine in Gastric Cancer. 330 $aThis book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section includes the pathological and clinical features and contains information regarding the most recent tissue and serological biomarkers in these neoplasms. The three successive sections are intended to provide the ?state of art? of multimodal treatment approaches to gastric cancer, i.e. standard and novel surgical aspects, common and innovative chemo and radio protocols and modern targeted therapies. Novel molecular classifications are under consideration to improve diagnostic and prognostic definitions and to prospect future treatments based on the use of immunotherapies and innovative molecules such as non-coding RNA and nanoparticles. Gastric Cancer in the Precision Medicine Era serves as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts. All chapters are written by experts in their fields and includes the most up to date scientific and clinical information. 410 0$aCurrent Clinical Pathology,$x2197-781X 606 $aPathology 606 $aGastroenterology 606 $aSurgery 606 $aOncology 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061 606 $aGeneral Surgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H59044 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aPathology. 615 0$aGastroenterology. 615 0$aSurgery. 615 0$aOncology. 615 14$aPathology. 615 24$aGastroenterology. 615 24$aGeneral Surgery. 615 24$aOncology. 676 $a616.99433 676 $a616.99433 702 $aCanzonieri$b Vincenzo$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGiordano$b Antonio$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910337481903321 996 $aGastric Cancer In The Precision Medicine Era$91734937 997 $aUNINA