LEADER 04199nam 22005535 450 001 9910320753203321 005 20200705062356.0 010 $a3-030-01993-4 024 7 $a10.1007/978-3-030-01993-8 035 $a(CKB)4100000007881157 035 $a(MiAaPQ)EBC5754729 035 $a(DE-He213)978-3-030-01993-8 035 $a(PPN)235670758 035 $a(EXLCZ)994100000007881157 100 $a20190408d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvances in Heart Valve Biomechanics $eValvular Physiology, Mechanobiology, and Bioengineering /$fedited by Michael S. Sacks, Jun Liao 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (500 pages) 311 $a3-030-01991-8 327 $aBiological Mechanics of the Heart Valve Interstitial Cell -- Endothelial Mechanotransduction -- The Role of Proteoglycans and Glycosaminoglycans in Heart Valve Biomechanics -- On the Unique Functional Elasticity and Collagen Fiber kinematics of Heart Valve Leaflets -- Tricuspid Valve Biomechanics: A Brief Review -- Measurement Technologies for Heart Valve Function -- Calcific Aortic Valve Disease: Pathobiology, Basic Mechanisms, and Clinical Strategies -- Remodeling Potential of the Mitral Heart Valve Leaflet -- Molecular and Cellular Developments in Heart Valve Development and Disease -- Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease -- Tissue Engineered Heart Valves -- Decellularization in Heart Valve Tissue Engineering -- Novel Bioreactors for Mechanistic Studies of Engineered Heart Valves -- Bioprosthetic Heart Valves: From a Biomaterials Perspective -- Computational Modeling of Heart Valves: Understanding and Predicting Disease -- Biomechanics and Modeling of Tissue-Engineered Heart Valves -- Fluid?structure interaction analysis of bioprosthetic heart valves: the application of a computationally-efficient tissue constitutive model -- Towards Patient-Specific Mitral Valve Surgical Simulations. 330 $aThis book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students. 606 $aRegenerative medicine 606 $aTissue engineering 606 $aBiomedical engineering 606 $aBiotechnology 606 $aRegenerative Medicine/Tissue Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/L16080 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aBiotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/C12002 615 0$aRegenerative medicine. 615 0$aTissue engineering. 615 0$aBiomedical engineering. 615 0$aBiotechnology. 615 14$aRegenerative Medicine/Tissue Engineering. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aBiotechnology. 676 $a591.1852 676 $a571.43 702 $aSacks$b Michael S$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLiao$b Jun$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910320753203321 996 $aAdvances in Heart Valve Biomechanics$92529081 997 $aUNINA