LEADER 02252nam  2200421   450 
001 9910317613203321
005 20230718231847.0
010   $a953-51-6935-1
035   $a(CKB)4970000000097952
035   $a(NjHacI)994970000000097952
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/65888
035   $a(EXLCZ)994970000000097952
100   $a20221020d2012      uy             0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aPancreatic Cancer $eMolecular Mechanism and Targets /$fedited by Sanjay K. Srivastava
210   $cIntechOpen$d2012
210  1$a[Place of publication not identified] :$cIntechOpen,$d2012.
215   $a1 online resource (446 pages)
311   $a953-51-0410-1 
320   $aIncludes bibliographical references and index.
330   $aThis book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-fluorouracil.
517   $aPancreatic Cancer
606   $aOncology
610   $aOncology
615  0$aOncology.
676   $a616.994
700   $aSrivastava$b Sanjay K$4edt$01370249
702   $aSrivastava$b Sanjay K.
801  0$bNjHacI
801  1$bNjHacl
906   $aBOOK
912   $a9910317613203321
996   $aPancreatic Cancer$93397913
997   $aUNINA