LEADER 00962nam0 2200313 450 001 9910312257503321 005 20190313160426.0 010 $a9780230506992 100 $a20190313d2007----km y0itay50 ba 101 0 $aeng 102 $aUS 105 $a 001yy 200 1 $aGlobal children, global media$emigration, media and childhood$fLiesbeth de Block, David Buckingham 210 $aNew York$cPalgrave Macmillan$d2007 215 $aXII, 222 p.$cill.$d23 cm 610 0 $aMezzi di comunicazione di massa 610 0 $aGlobalizzazione$aAspetti sociali 610 0 $aImmigrati$aMinori 676 $a302.23083$v22$zita 676 $a304.8$v22$zita 700 1$ade Block,$bLiesbeth$0762646 701 1$aBuckingham,$bDavid$0618985 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910312257503321 952 $a302.23083 DEB 1$b5951$fBFS 959 $aBFS 996 $aGlobal children, global media$91546321 997 $aUNINA LEADER 02328nam 2200493z- 450 001 9910557255303321 005 20211118 035 $a(CKB)5400000000041404 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73755 035 $a(oapen)doab73755 035 $a(EXLCZ)995400000000041404 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUpdates on Osteoimmunology: What's New on the Crosstalk Between Bone and Immune Cells 210 $cFrontiers Media SA$d2020 215 $a1 online resource (170 p.) 311 08$a2-88963-613-5 330 $aIn the last twenty years, different discoveries have emphasized the cross-talk between bone and immune cells as well as their common regulatory pathways. Indeed, soluble molecules produced by immune cells modulate the behavior of osteoblasts and osteoclasts. Moreover, osteoclasts, the bone-resorbing cells, originate from the same myeloid precursor cells that differentiated into macrophages and myeloid dendritic cells. Whereas, the bone-forming osteoblastic cells control hematopoietic stem cell niches and thus immune cell ontology. The amplified recognition of the complex relationship between the immune system and bone led to the designation of osteoimmunology field. This Research Topic collects articles that highlight the cross-talk between bone and immune cells, 517 $aUpdates on Osteoimmunology 606 $aEndocrinology$2bicssc 606 $aMedicine and Nursing$2bicssc 610 $aimmune cell 610 $aosteoblast 610 $aosteoclast 610 $aosteocyte 610 $aosteoimmunology 615 7$aEndocrinology 615 7$aMedicine and Nursing 700 $aBrunetti$b Giacomina$4edt$01328497 702 $aD?Amelio$b Patrizia$4edt 702 $aMori$b Giorgio$4edt 702 $aFelicia Faienza$b Maria$4edt 702 $aBrunetti$b Giacomina$4oth 702 $aD?Amelio$b Patrizia$4oth 702 $aMori$b Giorgio$4oth 702 $aFelicia Faienza$b Maria$4oth 906 $aBOOK 912 $a9910557255303321 996 $aUpdates on Osteoimmunology: What?s New on the Crosstalk Between Bone and Immune Cells$93038614 997 $aUNINA LEADER 05322nam 2201393z- 450 001 9910557545203321 005 20220111 035 $a(CKB)5400000000044155 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76606 035 $a(oapen)doab76606 035 $a(EXLCZ)995400000000044155 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSphingolipids$eFrom Pathology to Therapeutic Perspectives - A Themed Honorary Issue to Prof. Lina Obeid 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (292 p.) 311 08$a3-03943-957-X 311 08$a3-03943-958-8 330 $aAlthough sphingolipids are ubiquitous components of cellular membranes, their abundance in cells is generally lower than glycerolipids or cholesterol, representing less than 20% of total lipid mass. Following their discovery in the brain-which contains the largest amounts of sphingolipids in the body-and first description in 1884 by J.L.W. Thudichum, sphingolipids have been overlooked for almost a century, perhaps due to their complexity and enigmatic nature. When sphingolipidoses were discovered, a series of inherited diseases caused by enzyme mutations involved in sphingolipid degradation returned to the limelight. The essential breakthrough came decades later, in the 1990s, with the discovery that sphingolipids were not just structural elements of cellular membranes but intra- and extracellular signaling molecules. It turned out that their lipid backbones, including ceramide and sphingosine-1-phosphate, had selective physiological functions. Thus, sphingolipids emerged as essential players in several pathologies including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The present volume reflects upon the unexpectedly eclectic functions of sphingolipids in health, disease, and therapy. This fascinating lipid class will continue to be the subject of up-and-coming future discoveries, especially with regard to new therapeutic strategies. 517 $aSphingolipids 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $aacid sphingomyelinase 610 $aalbumin 610 $aallyl carbamate derivative 610 $aanimal models 610 $aanxiety 610 $aanxiety-like behavior 610 $aapoptosis 610 $aAspergillus fumigatus 610 $aastrocytes 610 $aautophagy 610 $abarrier dysfunction 610 $abeta-cells 610 $acalcium 610 $acancer 610 $acardioprotection 610 $aceramidase 610 $aceramidases 610 $aceramide 610 $aceramides 610 $aCLN3 disease 610 $aCln3?ex7/8 mice 610 $acoronary flow 610 $acortex 610 $acystic fibrosis 610 $acytokines 610 $adepression 610 $adepressive-like behavior 610 $afingolimod 610 $aflupirtine 610 $aforebrain 610 $aG-protein-coupled receptors 610 $agangliosides 610 $aG?q/11 610 $ahippocampus 610 $ahistone acetylation 610 $ahypothalamus 610 $ahypoxia 610 $aimmunotherapy 610 $ainfectious diseases 610 $ainflammation 610 $ainsulin 610 $ainsulin resistance 610 $aischemia/reperfusion 610 $aislets 610 $along non-coding RNA 610 $ametastasis 610 $amicroRNA 610 $amultiple sclerosis 610 $amyocardial function 610 $amyocardial infarct 610 $amyriocin 610 $an/a 610 $aneurodegeneration 610 $aneurodegenerative diseases 610 $aneurons 610 $aobesity 610 $apancreatic ? cell fate 610 $aphenotype switching 610 $aS1P 610 $aS1P receptor 610 $aS1P transporter 610 $aS1P-lyase (SGPL1) 610 $aS1P1-5 610 $aSK1 610 $aSmpd1 610 $asphingolipids 610 $asphingomyelinase 610 $asphingosine 1-phoshate 610 $asphingosine 1-phosphate 610 $aSphingosine 1-phosphate (S1P) 610 $asphingosine 1-phosphate antagonistst/inhibitors 610 $asphingosine 1-phosphate metabolism 610 $asphingosine 1-phosphate receptor 610 $asphingosine 1-phosphate signaling 610 $asphingosine kinase 610 $asphingosine kinase 1 610 $asphingosine-1-phosphate 610 $aSphingosine-1-phosphate 610 $aspinster homolog 2 610 $astroke 610 $atau 610 $atranscription factor 610 $atype 1 diabetes 610 $atype 2 diabetes 610 $avasoconstriction 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $avan Echten-Deckert$b Gerhild$4edt$01307154 702 $avan Echten-Deckert$b Gerhild$4oth 906 $aBOOK 912 $a9910557545203321 996 $aSphingolipids$93028702 997 $aUNINA