LEADER 04101nam 22005055 450 001 9910311940003321 005 20200703114556.0 010 $a3-030-03526-3 024 7 $a10.1007/978-3-030-03526-6 035 $a(CKB)4100000007598572 035 $a(MiAaPQ)EBC5683098 035 $a(DE-He213)978-3-030-03526-6 035 $a(PPN)23500670X 035 $a(EXLCZ)994100000007598572 100 $a20190205d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Sliding-Filament Theory of Muscle Contraction /$fby David Aitchison Smith 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (433 pages) 311 $a3-030-03525-5 330 $aUnderstanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories. 606 $aHuman physiology 606 $aMolecular biology 606 $aCell physiology 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 615 0$aHuman physiology. 615 0$aMolecular biology. 615 0$aCell physiology. 615 14$aHuman Physiology. 615 24$aMolecular Medicine. 615 24$aCell Physiology. 676 $a612 676 $a573.75 700 $aAitchison Smith$b David$4aut$4http://id.loc.gov/vocabulary/relators/aut$01062911 906 $aBOOK 912 $a9910311940003321 996 $aThe Sliding-Filament Theory of Muscle Contraction$92529080 997 $aUNINA