LEADER 04622nam 22006375 450 001 9910309663603321 005 20200705084154.0 010 $a3-030-02771-6 024 7 $a10.1007/978-3-030-02771-1 035 $a(CKB)4100000007389680 035 $a(MiAaPQ)EBC5630980 035 $a(DE-He213)978-3-030-02771-1 035 $a(PPN)233796142 035 $a(EXLCZ)994100000007389680 100 $a20190108d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTargeted Therapy of Colorectal Cancer Subtypes /$fedited by Peter Jordan 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (152 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1110 311 $a3-030-02770-8 327 $aPreface -- Colorectal Cancer Subtypes- the current portrait -- Targeting colon cancers with mutated BRAF and microsatellite instability -- Targeting KRAS mutant CMS3 subtype by metabolic inhibitors -- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer -- Targeting PTEN in colorectal cancers -- Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment?- Impact of the microenvironment on tumour budding in colorectal cancer -- Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all -- miRNAs as modulators of EGFR therapy in colorectal cancer -- Index. 330 $aIn this book, a group of researchers shares their expertise on the identification and characterization of genetic colorectal cancer subtypes. They describe solid pathobiological knowledge on the distinct sporadic tumour subtypes, including the mutations found in oncogenes and tumour suppressor genes, the types of genomic instability encountered, and the cellular signalling pathways activated. The book content indicates opportunities for the development of further pathway-specific therapeutic drugs or drug combinations, allowing to cope with the appearance of resistant tumours. The nine chapters of this book cover the main aspects underlying colorectal cancer development but also of its therapeutic options, which have been undergoing substantial changes by moving from the use of general cytotoxic agents that affect rapidly growing cells to more tumour-specific drugs. In the first case, all dividing cells in the patient?s body are affected and this causes severe and debilitating side effects. In the second case, the increasing knowledge about the molecular genetics of tumours has led to a new generation of drugs, which specifically interfere with the cell survival pathways that are activated in a given tumour. This allowed to identify groups of patients for targeted therapy that is much better tolerated. The book is thus an interesting update for health professionals on the current knowledge on heterogeneity in colorectal cancer. In addition, it should inspire the drug-developing scientific community by highlighting potential therapeutic Achilles heels of distinct subtypes of colorectal cancer. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v1110 606 $aCancer research 606 $aHuman genetics 606 $aMolecular biology 606 $aBiomedical engineering 606 $aImmunology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aBiomedical Engineering/Biotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/B24000 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 615 0$aCancer research. 615 0$aHuman genetics. 615 0$aMolecular biology. 615 0$aBiomedical engineering. 615 0$aImmunology. 615 14$aCancer Research. 615 24$aHuman Genetics. 615 24$aMolecular Medicine. 615 24$aBiomedical Engineering/Biotechnology. 615 24$aImmunology. 676 $a616.99435061 676 $a616.994347061 702 $aJordan$b Peter$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910309663603321 996 $aTargeted Therapy of Colorectal Cancer Subtypes$92526777 997 $aUNINA