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010   $a3-030-03556-5
024 7 $a10.1007/978-3-030-03556-3
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035   $a(MiAaPQ)EBC5611143
035   $a(DE-He213)978-3-030-03556-3
035   $a(PPN)232964963
035   $a(EXLCZ)994100000007181304
100   $a20181205d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aSurface Enhanced Raman Spectroscopy for Biophysical Applications $eUsing Plasmonic Nanoparticle Assemblies /$fby Claudia Fasolato
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (167 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
311   $a3-030-03555-7 
327   $aIntroduction -- Traditional Raman and SERS: fundamentals and state of the art -- Investigation on nanoparticles and their molecular functionalization -- Nanoparticle-based SERS substrates for molecular sensing applications -- SERS-active nanovectors for single-cell cancer screening and theranostics -- Conclusions.
330   $aThe book explores the phenomenon of surface-enhanced Raman scattering (SERS), the huge amplification of Raman signal from molecules in the proximity of a metallic nanostructured surface, allowing readers to gain an in-depth understanding of the mechanisms affecting the spectroscopic response of SERS-active systems for effective applications. SERS spectroscopy is an ultrasensitive analytical technique with great potential for applications in the field of biophysics and nanomedicine. As examples, the author presents the design of nanocolloid-based SERS-active substrates for molecular sensing and of a folate-based SERS-active nanosensor capable of selectively interacting with cancer cells, enabling cancer diagnostics and therapy at the single-cell level. The author also suggests novel paths for the systematization of the SERS nanosystem design and experimental protocols to maximize sensitivity and reproducibility, which is essential when real-world biomedical applications are the goal of the study. With a combined approach, both fundamental and applied, and a detailed analysis of the state of the art, this book provides a valuable overview both for students new to SERS spectroscopy and for experts in the field.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aSpectrum analysis
606   $aMicroscopy
606   $aBiophysics
606   $aBiophysics
606   $aSurfaces (Physics)
606   $aInterfaces (Physical sciences)
606   $aThin films
606   $aSpectroscopy and Microscopy$3https://scigraph.springernature.com/ontologies/product-market-codes/P31090
606   $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008
606   $aSurface and Interface Science, Thin Films$3https://scigraph.springernature.com/ontologies/product-market-codes/P25160
615  0$aSpectrum analysis.
615  0$aMicroscopy.
615  0$aBiophysics.
615  0$aBiophysics.
615  0$aSurfaces (Physics)
615  0$aInterfaces (Physical sciences)
615  0$aThin films.
615 14$aSpectroscopy and Microscopy.
615 24$aBiological and Medical Physics, Biophysics.
615 24$aSurface and Interface Science, Thin Films.
676   $a535.846
700   $aFasolato$b Claudia$4aut$4http://id.loc.gov/vocabulary/relators/aut$01063734
906   $aBOOK
912   $a9910303444103321
996   $aSurface Enhanced Raman Spectroscopy for Biophysical Applications$92534280
997   $aUNINA