LEADER 04877nam 22007455 450 001 9910303438503321 005 20200701135437.0 010 $a3-319-99546-4 024 7 $a10.1007/978-3-319-99546-5 035 $a(CKB)4100000007335064 035 $a(DE-He213)978-3-319-99546-5 035 $a(MiAaPQ)EBC6311857 035 $a(PPN)232965749 035 $a(EXLCZ)994100000007335064 100 $a20181229d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLessons on Caffeine, Cannabis & Co $ePlant-derived Drugs and their Interaction with Human Receptors /$fby Angelika Böttger, Ute Vothknecht, Cordelia Bolle, Alexander Wolf 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (X, 217 p. 69 illus., 50 illus. in color.) 225 1 $aLearning Materials in Biosciences,$x2509-6125 311 $a3-319-99545-6 327 $aIntroduction: Plant secondary metabolites and their general function in plants -- Historical and current perspective -- Medicinal use -- Recreational use -- General overview over biosynthesis pathways of plant secondary metabolites -- Drugs affecting GPCR: GPCRs in plants and animals -- Dopamine and 5-HT2A-serotonin receptors ? Cocaine, mescaline, psilobin -- Opiate receptors ? morphine, salvinorin A -- Cannabinoid receptors ? THC -- Muscarinergic acetylcholin receptor - muscarin, atropine -- Adenosine receptor ? caffeine -- Drugs affecting ion channels: Ligand and voltage activated channels -- Nicotinic acetylcholin receptor ? Nicotine, Curare -- GABAA/C-receptor ? Muscimol, thujone -- ionotropic Glycine receptor ? Strychnine -- ionotropic Glutamate receptor - ibogtenic acid, kainic acid -- TRP channels ? capsaicin, menthol, aconitine, resiniferatoxin -- Anti-cancer drugs acting on the cell cycle: Cell cycle in animals and plants -- Microtubuli - Colchicine, taxol, vinblastine, Podophyllotoxin (Lignan) -- Topoisomerase - camptothecin, etoposide -- G2/M phase arrest, apoptosis ? curcubitacin, triptolide. 330 $aThis textbook provides a structured, easy to understand and thorough insight into the mode of function of plant secondary metabolites in plants and humans. It explains the biosynthesis and molecular action of nicotine, cannabis, caffeine and Co, describes the effects of these drugs on signal transduction at receptors and ion channels in animals, their relevance for human health and their potential for recreational use and abuse. It also offers a broad and comprehensive understanding on the role and function of these diverse molecules for the plants that make them. This textbook is written for master students and scientist in biochemistry and biology as well as for pharmaceutical and medical students. It will be a valuable study tool for teachers and students alike. 410 0$aLearning Materials in Biosciences,$x2509-6125 606 $aPharmacology 606 $aBotanical chemistry 606 $aScience$xStudy and teaching 606 $aBiotechnology 606 $aCancer$xResearch 606 $aMolecular biology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aPlant Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14021 606 $aScience Education$3https://scigraph.springernature.com/ontologies/product-market-codes/O27000 606 $aBiotechnology$3https://scigraph.springernature.com/ontologies/product-market-codes/C12002 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aPharmacology. 615 0$aBotanical chemistry. 615 0$aScience$xStudy and teaching. 615 0$aBiotechnology. 615 0$aCancer$xResearch. 615 0$aMolecular biology. 615 14$aPharmacology/Toxicology. 615 24$aPlant Biochemistry. 615 24$aScience Education. 615 24$aBiotechnology. 615 24$aCancer Research. 615 24$aMolecular Medicine. 676 $a613.84 700 $aBöttger$b Angelika$4aut$4http://id.loc.gov/vocabulary/relators/aut$01060400 702 $aVothknecht$b Ute$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBolle$b Cordelia$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aWolf$b Alexander$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910303438503321 996 $aLessons on Caffeine, Cannabis & Co$92513345 997 $aUNINA