LEADER 01682nas 2200481-a 450 001 996198099803316 005 20240413024441.0 035 $a(CKB)111022263597006 035 $a(CONSER)---72621476- 035 $a(EXLCZ)99111022263597006 100 $a20750812b19721972 --- a 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBusiness and society review 210 $aBoston, Mass. $cWarren, Gorham & Lamont$d©1972 215 $a1 online resource 300 $aRefereed/Peer-reviewed 300 $a"A quarterly forum on the role of business in a free society." 311 08$aPrint version: Business and society review (Boston, Mass.) 0893-4398 (DLC) 72621476 (OCoLC)1537870 531 $aBUSINESS & SOCIETY REVIEW 531 0 $aBus. soc. rev. 606 $aIndustries$xSocial aspects$zUnited States$vPeriodicals 606 $aIndustrie$xAspect social$zÉtats-Unis$vPériodiques 606 $aIndustries$xSocial aspects$2fast$3(OCoLC)fst00971967 606 $aBedrijfsleven$2gtt 606 $aMaatschappij$2gtt 607 $aUnited States$2fast$1https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq 608 $aPeriodicals.$2fast 608 $aPeriodicals.$2lcgft 615 0$aIndustries$xSocial aspects 615 6$aIndustrie$xAspect social 615 7$aIndustries$xSocial aspects. 615 17$aBedrijfsleven. 615 17$aMaatschappij. 676 $a658.4/08/05 712 02$aWarren, Gorham & Lamont. 906 $aJOURNAL 912 $a996198099803316 920 $aexl_impl conversion 996 $aBusiness and society review$92058442 997 $aUNISA LEADER 04450nam 22007695 450 001 9910303438503321 005 20251202120703.0 010 $a3-319-99546-4 024 7 $a10.1007/978-3-319-99546-5 035 $a(CKB)4100000007335064 035 $a(DE-He213)978-3-319-99546-5 035 $a(MiAaPQ)EBC6311857 035 $a(PPN)232965749 035 $a(EXLCZ)994100000007335064 100 $a20181229d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLessons on Caffeine, Cannabis & Co $ePlant-derived Drugs and their Interaction with Human Receptors /$fby Angelika Böttger, Ute Vothknecht, Cordelia Bolle, Alexander Wolf 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (X, 217 p. 69 illus., 50 illus. in color.) 225 1 $aLearning Materials in Biosciences,$x2509-6133 311 08$a3-319-99545-6 327 $aIntroduction: Plant secondary metabolites and their general function in plants -- Historical and current perspective -- Medicinal use -- Recreational use -- General overview over biosynthesis pathways of plant secondary metabolites -- Drugs affecting GPCR: GPCRs in plants and animals -- Dopamine and 5-HT2A-serotonin receptors ? Cocaine, mescaline, psilobin -- Opiate receptors ? morphine, salvinorin A -- Cannabinoid receptors ? THC -- Muscarinergic acetylcholin receptor - muscarin, atropine -- Adenosine receptor ? caffeine -- Drugs affecting ion channels: Ligand and voltage activated channels -- Nicotinic acetylcholin receptor ? Nicotine, Curare -- GABAA/C-receptor ? Muscimol, thujone -- ionotropic Glycine receptor ? Strychnine -- ionotropic Glutamate receptor - ibogtenic acid, kainic acid -- TRP channels ? capsaicin, menthol, aconitine, resiniferatoxin -- Anti-cancer drugs acting on the cell cycle: Cell cycle in animals and plants -- Microtubuli - Colchicine, taxol, vinblastine, Podophyllotoxin (Lignan) -- Topoisomerase - camptothecin, etoposide -- G2/M phase arrest, apoptosis ? curcubitacin, triptolide. 330 $aThis textbook provides a structured, easy to understand and thorough insight into the mode of function of plant secondary metabolites in plants and humans. It explains the biosynthesis and molecular action of nicotine, cannabis, caffeine and Co, describes the effects of these drugs on signal transduction at receptors and ion channels in animals, their relevance for human health and their potential for recreational use and abuse. It also offers a broad and comprehensive understanding on the role and function of these diverse molecules for the plants that make them. This textbook is written for master students and scientist in biochemistry and biology as well as for pharmaceutical and medical students. It will be a valuable study tool for teachers and students alike. 410 0$aLearning Materials in Biosciences,$x2509-6133 606 $aPharmacology 606 $aBotanical chemistry 606 $aScience$xStudy and teaching 606 $aBiotechnology 606 $aCancer 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aPharmacology 606 $aPlant Biochemistry 606 $aScience Education 606 $aBiotechnology 606 $aCancer Biology 606 $aBiomedical Research 615 0$aPharmacology. 615 0$aBotanical chemistry. 615 0$aScience$xStudy and teaching. 615 0$aBiotechnology. 615 0$aCancer. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aPharmacology. 615 24$aPlant Biochemistry. 615 24$aScience Education. 615 24$aBiotechnology. 615 24$aCancer Biology. 615 24$aBiomedical Research. 676 $a613.84 700 $aBöttger$b Angelika$4aut$4http://id.loc.gov/vocabulary/relators/aut$01060400 702 $aVothknecht$b Ute$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBolle$b Cordelia$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aWolf$b Alexander$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910303438503321 996 $aLessons on Caffeine, Cannabis & Co$92513345 997 $aUNINA