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010   $a3-319-98255-9
024 7 $a10.1007/978-3-319-98255-7
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035   $a(MiAaPQ)EBC5491451
035   $a(DE-He213)978-3-319-98255-7
035   $a(PPN)229915531
035   $a(EXLCZ)994100000005679250
100   $a20180809d2018      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aSpectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging /$fby Anna Siri Luthman
205   $a1st ed. 2018.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018.
215   $a1 online resource (153 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
311   $a3-319-98254-0 
327   $aSummary and Rationale -- Spectral Imaging Systems and Sensor Characterisations -- Wide-field fHSI with a Linescan SRDA -- A Multispectral Endoscope Based on SRDAs -- Conclusions and Outlook.
330   $aThis book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes ? a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of a bimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model. This is the first book to demonstrate the potential of SRDAs for fluorescence imaging in biomedicine, opening up a new multidisciplinary research direction.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053
606   $aSpectrum analysis
606   $aMicroscopy
606   $aBiophysics
606   $aBiophysics
606   $aPhysical measurements
606   $aMeasurement
606   $aSpectroscopy and Microscopy$3https://scigraph.springernature.com/ontologies/product-market-codes/P31090
606   $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008
606   $aMeasurement Science and Instrumentation$3https://scigraph.springernature.com/ontologies/product-market-codes/P31040
615  0$aSpectrum analysis.
615  0$aMicroscopy.
615  0$aBiophysics.
615  0$aBiophysics.
615  0$aPhysical measurements.
615  0$aMeasurement.
615 14$aSpectroscopy and Microscopy.
615 24$aBiological and Medical Physics, Biophysics.
615 24$aMeasurement Science and Instrumentation.
676   $a535.84
700   $aLuthman$b Anna Siri$4aut$4http://id.loc.gov/vocabulary/relators/aut$01064360
906   $aBOOK
912   $a9910300557303321
996   $aSpectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging$92537609
997   $aUNINA