LEADER 05620nam 22006615 450 001 9910300533503321 005 20200703183341.0 010 $a978-981-13-0472-9 010 $a981-13-0472-6 024 7 $a10.1007/978-981-13-0472-9 035 $a(CKB)4100000004244378 035 $a(MiAaPQ)EBC5402148 035 $a(DE-He213)978-981-13-0472-9 035 $a(PPN)227399390 035 $a(EXLCZ)994100000004244378 100 $a20180524d2018 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 12$aA Polymer Cochlear Electrode Array: Atraumatic Deep Insertion, Tripolar Stimulation, and Long-Term Reliability /$fby Tae Mok Gwon 205 $a1st ed. 2018. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018. 215 $a1 online resource (107 pages) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a981-13-0471-8 327 $aAbstract -- Contents -- List of Figures -- List of Tables -- List of Abbreviations -- Chapter 1 Introduction -- 1.1 Overview of Neural Prostheses and Cochlear Implants -- 1.2 Review of Cochlear Electrode Arrays -- 1.3 Proposed Polymer Cochlear Electrode Array -- 1.4 Long-Term Reliability of Polymer-Based Neural Prostheses -- 1.5 Objectives of the Dissertation -- Chapter 2 Materials and Methods -- 2.1 Liquid Crystal Polymer (LCP) -- 2.2 Cochlear Electrode Array for Atraumatic Deep Insertion -- 2.3 Polymer Electrode Array for Tripolar Stimulation -- 2.4 Long-Term Reliability Analysis of LCP-Based Neural Implants -- Chapter 3 Results -- 3.1 LCP-Based Cochlear Electrode Array for Atraumatic Deep Insertion -- 3.2 Polymer Electrode Array for Tripolar Stimulation -- 3.3 Long-Term Device Reliability -- Method -- Chapter 4 Discussion -- 4.1 LCP-Based Cochlear Electrode Arraysfor Atraumatic Deep Insertion -- 4.2 Power Consumption and Stimulation Threshold of Tripolar Stimulation -- 4.3 Technical Strategies to Improve Device Reliability -- 4.4 Review of Long-Term Reliability of LCP-Based Devices -- Chapter 5 Conclusion -- References. 330 $aThis book describes the design, fabrication and evaluation of a polymer-based neural interface for a cochlear electrode array, reviewed in terms of fabrication process, functionality, and reliability. Polymer-based devices have attracted attention in the neural prosthetic field due to their flexibility and compatibility with micro-fabrication process. A liquid crystal polymer (LCP) is an inert, highly water-resistant polymer suitable for the encapsulation of electronic components and as a substrate material for fabricating neural interfaces. The author has designed, fabricated, and evaluated an LCP-based cochlear electrode array for an improved polymer-based cochlear implant. The thesis deals with 3 key topics: atraumatic deep insertion, tripolar stimulation, and long-term reliability. Atraumatic insertion of the intracochlear electrode and resulting preservation of residual hearing have become essential in state?of-the-art cochlear implantation. A novel tapered design of an LCP-based cochlear electrode array is presented to meet such goals. For high-density and pitch-recognizable cochlear implant, channel interaction should be avoided. Local tripolar stimulation using multi-layered electrode sites are shown to achieve highly focused electrical stimulation. This thesis addresses another vital issue in the polymer-based neural implants: the long-term reliability issue. After suggesting a new method of forming mechanical interlocking to improve polymer-metal adhesion, the author performs accelerating aging tests to verify the method?s efficacy. The aforementioned three topics have been thoroughly examined through various in vitro and in vivo studies. Verification foresees the development of LCP-based cochlear electrode array for an atraumatic deep insertion, advanced stimulation, and long-term clinical implant. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aElectronic circuits 606 $aBiomedical engineering 606 $aMaterials?Surfaces 606 $aThin films 606 $aPolymers 606 $aMicroarrays 606 $aElectronic Circuits and Devices$3https://scigraph.springernature.com/ontologies/product-market-codes/P31010 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aSurfaces and Interfaces, Thin Films$3https://scigraph.springernature.com/ontologies/product-market-codes/Z19000 606 $aPolymer Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/C22008 606 $aMicroarrays$3https://scigraph.springernature.com/ontologies/product-market-codes/B12050 615 0$aElectronic circuits. 615 0$aBiomedical engineering. 615 0$aMaterials?Surfaces. 615 0$aThin films. 615 0$aPolymers. 615 0$aMicroarrays. 615 14$aElectronic Circuits and Devices. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aSurfaces and Interfaces, Thin Films. 615 24$aPolymer Sciences. 615 24$aMicroarrays. 676 $a617.89 700 $aGwon$b Tae Mok$4aut$4http://id.loc.gov/vocabulary/relators/aut$0835609 906 $aBOOK 912 $a9910300533503321 996 $aA Polymer Cochlear Electrode Array: Atraumatic Deep Insertion, Tripolar Stimulation, and Long-Term Reliability$92529260 997 $aUNINA