LEADER 05423nam 22005175 450 001 9910300443303321 005 20200629210638.0 010 $a981-10-8144-1 024 7 $a10.1007/978-981-10-8144-6 035 $a(CKB)4100000005248383 035 $a(DE-He213)978-981-10-8144-6 035 $a(MiAaPQ)EBC5452106 035 $a(PPN)229499635 035 $a(EXLCZ)994100000005248383 100 $a20180712d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClinical Relevance of Genetic Factors in Pulmonary Diseases /$fedited by Takeshi Kaneko 205 $a1st ed. 2018. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018. 215 $a1 online resource (IX, 344 p. 55 illus., 36 illus. in color.) 225 1 $aRespiratory Disease Series: Diagnostic Tools and Disease Managements,$x2509-5552 311 $a981-10-8143-3 327 $aPart I?Introduction -- 1. Clinical development of genomic medicine in pulmonary diseases: Are genetic factors enough to determine the phenotype and inheritance of pulmonary diseases? -- 2. Statistical approaches and strategies for complex diseases - Overview - : What is the rationale for the genome-wide approach to understand complex diseases - its application and limitations -- Part II?Genetic Disorders in Pulmonary Disease -- 3 (?4)Bronchial asthma: Is asthma inherited? -- 4 (?5)COPD - Hereditary (A1-AT) and Non-hereditary: What are the roles of genetic factors in the pathogenesis of COPD? -- 5 (?3)Smoking behavior and cessation (nicotine addiction): Are genetic factors involved in smoking behavior? -- 6. Cystic fibrosis, Primary ciliary dyskinesia and Diffuse panbronchiolitis - Hereditary and Non-Hereditary: What are the roles of genetic factors in the pathogenesis of these diseases? -- 7. Pulmonary Fibrosis -Hereditary and Nonhereditary: What are the role of genetic factors in the pathogenesis of pulmonary fibrosis? -- 8. Other diffuse lung diseases - Diffuse cystic lung diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary alveolar proteinosis, and Pulmonary alveolar microlithiasis: What are the roles of genetic factors in the pathogenesis of these diseases? -- 9. Pulmonary vascular diseases - Pulmonary hypertension and HHT: What are the roles of genetic factors in the pathogenesis of pulmonary vascular diseases? -- 10. Mycobacterial infection ? TB and NTM: What are the roles of genetic factors in the pathogenesis of mycobacterial infection? -- 11. Pulmonary malignancies (1): Lung cancer: What are the roles of genetic factors in lung cancer pathogenesis? -- 12. Pulmonary malignancies (2): Mesothelioma: What are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma? -- 13. Genetic Factors in Sleep Disorders: What are the roles of genetic factors in the pathogenesis of sleep disorders? -- 14. Pharmacokinetics, pharmacodynamics, and toxicities: What should we know about genetic factors that affect the pharmacotherapy of pulmonary diseases? -- Part III?Oncogenic Driver Mutation (Somatic Mutations) in Lung Cancer -- 15. EGFR: How important is EGFR mutation status in the management of lung cancer? -- 16. ALK, and others: How important are ALK, and other mutations in the management of lung cancer? -- Part IV?Current Topics -- 17.Application of high-throughput technologies in personal genomics: How is the progress in personal genome service? -- 18. Nucleic acid amplification-based diagnostics for pulmonary diseases : What is the current state and perspectives of nucleic acid amplification technologies used in diagnostics associated with pulmonary diseases?. 330 $aThis book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory Disease Series ? Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work. . 410 0$aRespiratory Disease Series: Diagnostic Tools and Disease Managements,$x2509-5552 606 $aRespiratory organs?Diseases 606 $aHuman genetics 606 $aPneumology/Respiratory System$3https://scigraph.springernature.com/ontologies/product-market-codes/H33134 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 615 0$aRespiratory organs?Diseases. 615 0$aHuman genetics. 615 14$aPneumology/Respiratory System. 615 24$aHuman Genetics. 676 $a616.2407 702 $aKaneko$b Takeshi$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300443303321 996 $aClinical Relevance of Genetic Factors in Pulmonary Diseases$91743147 997 $aUNINA