LEADER 00991nam--2200361---450- 001 990003272120203316 005 20090616094842.0 010 $a0-415-35876-0 035 $a000327212 035 $aUSA01000327212 035 $a(ALEPH)000327212USA01 035 $a000327212 100 $a20090616d2006----km-y0itay50------ba 101 $aeng 102 $aGB$aUS 105 $a||||||||001yy 200 1 $aWord from the mother$elanguage and African Americans$fGeneva Smitherman 210 $aLondon$aNew York$cRoutledge$d2006 215 $aXIII, 172 p.$cill.$d24 cm 410 0$12001 454 1$12001 461 1$1001-------$12001 606 0 $aAfro-americani$xLingua 676 $a427.089960973 700 1$aSMITHERMAN,$bGeneva$0604896 801 0$aIT$bsalbc$gISBD 912 $a990003272120203316 951 $aI.10.B.32$b9122 DSLL 959 $aBK 969 $aDSLL 979 $aDSLL$b90$c20090616$lUSA01$h0948 996 $aWord from the mother$91118348 997 $aUNISA LEADER 03925nam 22005775 450 001 9910300439403321 005 20200704084530.0 010 $a3-319-68082-X 024 7 $a10.1007/978-3-319-68082-8 035 $a(CKB)4100000001795030 035 $a(DE-He213)978-3-319-68082-8 035 $a(MiAaPQ)EBC5217037 035 $a(PPN)223956295 035 $a(EXLCZ)994100000001795030 100 $a20180109d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPrecision Molecular Pathology of Liver Cancer /$fedited by Chen Liu 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (XI, 271 p. 30 illus., 22 illus. in color.) 225 1 $aMolecular Pathology Library,$x1935-987X 311 $a3-319-68080-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aOverview: Current diagnosis and treatment of HCC in the era of precision medicine -- The etiology and pathogenesis of hepatocellular carcinoma -- Histological classification of HCC and its clinical implication -- Molecular classification of HCC and precision medicine -- Recent advances in HCC genomics, next generation sequencing, and bioinformatics -- Epigenetic regulations in the pathogenesis of HCC and the clinical application -- Biomarker discovery and validation in HCC diagnosis, prognosis, and therapy -- HCC cancer stem cell signaling pathway -- Epithelial and mesenchymal transition (EMT) and its biological significance in HCC -- HCC metastasis and circulating tumor cells -- Biological role and potential clinical application of miRNA in hepatocellular carcinoma -- Immune regulation in HCC and the prospect of immunotherapy -- Liver cell dysplasia and the development of HCC -- Molecular pathogenesis of hepatic adenoma and its malignant transformation -- The role of liver biopsy in HCC early diagnosis and treatment decision -- The future prospect on surgical approaches for HCC -- The future prospect on targeted therapy for HCC. . 330 $aThis volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma. . 410 0$aMolecular Pathology Library,$x1935-987X 606 $aPathology 606 $aGastroenterology 606 $aOncology 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aPathology. 615 0$aGastroenterology. 615 0$aOncology. 615 14$aPathology. 615 24$aGastroenterology. 615 24$aOncology. 676 $a616.99436075 702 $aLiu$b Chen$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910300439403321 996 $aPrecision Molecular Pathology of Liver Cancer$91754641 997 $aUNINA